Medicine

Chronic pelvic pain is a common and multifactorial clinical syndrome that markedly impairs quality of life in both men and women. Superior hypogastric plexus block (SHGPB) is an effective minimally invasive treatment. The sacral notch appro…

Patients with acute pancreatitis (AP) in the intensive care unit experience high complication and mortality rates, making early prognosis prediction crucial. While the aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio i…

Accumulating observational evidence suggests an association between thyroid function and endometriosis, though the causal relationship remains unclear. To investigate potential bidirectional causal relationships, including for endometriosis…

Ovarian cancer is one of the most lethal gynecological malignancies globally, with significant variations in incidence, prevalence, and outcomes across regions and population subgroups. This study systematically evaluates the global, region…

BACKGROUND: Dysmenorrhea impacts 45% to 95% of women of childbearing age globally. Research on the neuro-immune-endocrine regulatory network has grown by 22.3% annually over the past decade, yet the field faces challenges including fragment…

Hysterectomy is a common gynecological procedure, with growing evidence suggesting potential long-term metabolic consequences. Gallstone disease (GSD) is a prevalent condition strongly linked to metabolic disturbances. However, the direct a…

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a prevalent inflammatory disease of the sinuses that significantly diminishes patients' quality of life. Endoplasmic reticulum stress (ERS) is strongly associated with the initiation and …

Severe pneumonia is the leading cause of mortality in individuals with lung disease. Programmed cell death (PCD) is implicated in various pathologies; however, the precise relationship between severe pneumonia and PCD remains unclear. This …

To evaluate the impact of hepatitis B virus (HBV) carrier status on oocyte quality, embryonic development, and pregnancy outcomes in women with varying ovarian reserve undergoing in vitro fertilization and embryo transfer (IVF-ET). This ret…

Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent and associated with metabolic dysfunction, systemic inflammation, and increased cardiovascular risk. The C-reactive protein-Triglyceride-Glucose Index (CTI…

The risk of placenta accreta spectrum (PAS) associated with in vitro fertilization and embryo transfer (IVF-ET) in the context of mid-trimester pregnancy loss remains unclear. This study aimed to investigate the impact of IVF-ET on the inci…

Endometriosis, a chronic gynecological disorder, is increasingly linked to metabolic dysregulation. The lipid accumulation product (LAP) - a biomarker integrating waist circumference and triglycerides - may provide additional information on…

Endometriosis (EMs) is a prevalent gynecological disorder affecting reproductive-age women. Exosomes secreted by peripheral blood macrophages may participate in EMs progression. In this pilot translational study, exosomes from peripheral bl…

BACKGROUND: Recent studies have revealed that the anti-inflammatory properties of vitamin D may play a role in pain regulation. To systematically map the global research landscape on vitamin D and chronic or idiopathic pain from 2000 to 202…

RationaleUlcerative colitis (UC) and psoriasis are both chronic inflammatory diseases mediated by the immune system. Ixekizumab, used to treat psoriasis, carries a risk of inducing or exacerbating UC. Infliximab has also been reported to ex…

Pancreatitis contributes substantially to gastrointestinal mortality, yet its population-level burden remains incompletely characterized. We conducted a retrospective, population-based study using the Centers for Disease Control and Prevent…

RationaleGestational trophoblastic neoplasia, particularly choriocarcinoma, is a rare but aggressive malignancy arising from trophoblastic tissue. Primary tubal choriocarcinoma is exceptionally uncommon and often presents a diagnostic chall…

This study aimed to delineate the molecular profile underlying progesterone resistance in atypical endometrial hyperplasia (AEH), a precancerous condition associated with a high risk of malignant transformation. Using a retrospective cohort…

RATIONALE: Hysterosalpingo-contrast sonography (HyCoSy) is a commonly used technique for assessing fallopian tube patency. A well-recognized complication of this procedure is venous intravasation (VI), which refers to the unintended entry o…

This retrospective study investigated risk factors and clinical outcomes of placenta accreta in pregnancies complicated by pernicious placenta previa (PPP). A total of 177 women diagnosed with PPP and treated at our institution between July…

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting reproductive-aged women and is associated with an increased risk of early pregnancy loss (EPL). The underlying mechanisms remain multifactorial and poorly understood.…

This study aimed to investigate the factors affecting the decline of serum anti-Müllerian hormone (AMH) in reproductive-aged women following minimally invasive ovarian cystectomy. A retrospective cohort study was conducted using the medical…

Endometriosis is a common gynecological disease that can cause pelvic adhesions. Severe adhesions increase the difficulty of surgery, resulting in prolonged operation time, increased intraoperative bleeding, and increased complications such…

The independent causal effects of interrelated lifestyle behaviors and psychological states on women's gynecologic and obstetric health remain incompletely understood. We conducted a comprehensive Mendelian randomization (MR) study to disen…

To explore the material basis and network mechanism of the Guizhi Fuling pills in the treatment of endometriosis and endometrial polyps based on network pharmacology and machine learning. The effective constituents and targets of the Guizhi…