Clinical and experimental reproductive medicine

OBJECTIVE: Hydroxyethyl piperazine ethane sulfonic acid (HEPES)-buffered media have long been employed in assisted reproductive technology (ART) procedures; however, concerns persist regarding the impact of zwitterionic buffers on intrinsic…

ObjectiveThis study aimed to assess associations between the peripheral natural killer (pNK) cell percentage and women's age, body mass index (BMI), serum anti-Müllerian hormone (AMH), autoantibodies, and thrombophilia-related markers among…

OBJECTIVE: This study investigated whether the average oocyte quality index (AOQI), used as a dysmorphic oocyte scoring system, is higher in women with ovarian endometrioma than in those with unexplained infertility or diminished ovarian re…

OBJECTIVE: This study aimed to compare the expression of implantation-related genes in trophectoderm cells between normally developing (day 5) and delayed (day 6) euploid blastocysts. METHODS: Trophectoderm biopsies were performed on blast…

OBJECTIVE: Postoperative adhesions and inflammation remain major challenges following endometriosis surgery. Human amniotic membrane gel (HAG) has emerged as a potential therapeutic strategy with both anti-adhesive and anti-inflammatory pro…

OBJECTIVE: Endometriosis is a chronic inflammatory disorder that affects approximately 10% of reproductive-age women and is frequently associated with subfertility. This study evaluated the potential ameliorative effect of lactoferrin on en…

A broad range of genetic and epigenetic factors contributes to female infertility, a substantial proportion of which is related to ovulatory disorders. Any factor that disrupts the normal function of key ovarian components, including the fo…

OBJECTIVE: Nicotine, a principal constituent of tobacco smoke, disrupts female reproductive physiology. Quercetin, a flavonoid with both phytoestrogenic and antioxidant properties, may counteract this toxicity. This study aimed to evaluate …

OBJECTIVE: In the application of assisted reproductive technologies (ART), selection of the optimal sperm presents a challenge. This study introduces an innovative microfluidic device that utilizes rheotaxis to efficiently sort sperm, offer…

OBJECTIVE: To establish a standardized and reproducible rat model of endometriosis by refining the classic Vivian technique, with the aim of minimizing methodological variability and replicating key features of human disease. METHODS: Sixt…

OBJECTIVE: Pregnant women with coronavirus disease 2019 (COVID-19) are more likely than nonpregnant women to require admission to an intensive care unit, and many may require antiviral therapy. Remdesivir, an antiviral drug used to treat CO…

Among the primary objectives of contemporary assisted reproductive technology research are achieving the births of healthy singletons and improving overall fertility outcomes. Substantial advances have been made in refining the selection of…

OBJECTIVE: While obesity has been associated with poor reproductive outcomes, the specific factors affecting gametes remain unclear. Our primary objective was to assess the relationship between a couple's pre-pregnancy body mass index (BMI)…

OBJECTIVE: For successful embryo implantation in women with high pulsatility, uterine vascular resistance and pulsatility must be reduced. We examined the effects of amlodipine on uterine pulsatility index (PI), resistance index (RI), and e…

OBJECTIVE: Infertility and fertility treatment can lead to considerable physical, emotional, and psychological distress. These effects may be influenced by personality, familial bonds, and support systems within a sociocultural context. Thi…

OBJECTIVE: The Korean government implemented national insurance coverage for infertility treatment in 2017 and established a nationwide infertility treatment data collection system in 2018. This report analyzes infertility treatment cycles …

OBJECTIVE: Laser-assisted hatching (LAH) employs two distinct techniques: thinning and breaching. This study aimed to compare the clinical efficacy of combined thinning and breaching versus breaching alone in vitrified-warmed embryo or blas…

OBJECTIVE: In this study, we investigated whether adding autologous platelet-rich plasma (PRP) to the culture medium affects embryo development and clinical outcomes in patients with recurrent implantation failure (RIF). METHODS: This stud…

With the advent of metagenomics and 16S ribosomal RNA sequencing, growing attention has been dedicated to the endometrial microbiome. Research involving a relatively large cohort of healthy female participants has reported Lactobacillus dom…

OBJECTIVE: This study aimed to compare the thiol/disulfide balance, myeloperoxidase, and ischemia-modified albumin levels in the follicular fluid (FF) of poor ovarian response (POR) and normal ovarian response (NOR) women who received intra…

OBJECTIVE: Endometriosis (Endo) involves inflammation and angiogenesis within lesions, potentially causing embryo implantation failure. Paeonia lactiflora (PL) root exhibits anti-angiogenic and anti-inflammatory properties. This experiment …

OBJECTIVE: Follicular fluid (FF) oxidation-reduction potential (ORP) has shown promise as a predictor for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes has been demonstrated. This study aimed to determine the a…

To assess the effects of endometrial scratch injury (ESI) in infertile couples seeking fertility through non-in vitro fertilization (IVF) cycles. We conducted a comprehensive search of MEDLINE, EMBASE, Web of Science, Scopus, the Cochrane L…

OBJECTIVE: This study was conducted to investigate the impact of previous delivery mode on pregnancy outcomes in patients with secondary infertility after frozen-thawed embryo transfer. METHODS: This prospective observational study include…

Male infertility can be caused by genetic anomalies, endocrine disorders, inflammation, and exposure to toxic chemicals or gonadotoxic treatments. Therefore, several recent studies have concentrated on the preservation and restoration of fe…