The Journal of endocrinology

We report the effects that sectioning the superior ovarian nerve of infantile female rats has on their follicular development at different ages before puberty. Compared with the control group, sham-operated animals showed a significant decr…

Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a specific inhibitor of a group of proteolytic enzymes known as matrix metalloproteinases. These enzymes have been widely implicated in the process of tissue remodelling. Extensive remode…

We have recently found that administration of oestradiol-17 beta (OE2) to rats stimulates trabecular bone formation. It is not known, however, whether oestrogen has a similar action on bone formation rate under physiological circumstances. …

In women with endometriosis there is concern that therapeutic use of LH-releasing hormone (LHRH) analogues, to lower ovarian oestrogen production and control endometrial hyperplasia, leads to unwanted oestrogen-deficiency bone loss. We have…

We have previously shown that pregnancy-associated alpha 1-globulin, a small molecular weight (32 kDa) insulin-like growth factor-binding protein (IGF-BP), is quantitatively the major secretory protein product of the decidualized endometriu…

Granulosa cells from ovarian follicles (greater than or equal to 1 mm diameter) in Booroola ewes which are homozygous (FF) or heterozygous (F+) for the F gene have previously been shown to produce significantly more cAMP in response to FSH …

Endometrium and myometrium were collected at hysterectomy from 21 women with measured menstrual blood loss. Eight women complained of dysmenorrhea and the remaining 13 had pain-free periods. Specimens were obtained throughout the menstrual …

The ultrastructure of the luminal surface epithelium was compared in endometrial samples taken from 23 normally cycling women and from 22 patients submitted to ovarian stimulation with clomiphene citrate (100 mg/day for 5 days), human menop…

The objectives of this investigation were to determine whether decidual tissue possesses specific binding sites for prolactin, and to examine whether the locally produced prolactin-like hormone binds to these receptors. Characterization of …

Myosin light chain kinase activity and the amount of calmodulin were measured in rabbit myometrium after the rabbits had been treated with oestrogen, progesterone and human chorionic gonadotrophin, and also during pregnancy. Injections of o…

Concentrations of prostaglandin F2 alpha (PGF2 alpha) and prostaglandin E (PGE) were measured in endometrium from 18 women with ectopic pregnancies. In the nine pregnancies not associated with vaginal bleeding or an intra-uterine contracept…

Work in this laboratory has demonstrated the ability of theophylline to stimulate the release of immunoreactive luteinizing hormone (IRLH) and follicle-stimulating hormone (IRFSH) in organ cultures of human foetal pituitary glands (Groom, G…

SUMMARY The influence of oestradiol-17β and/or progesterone on decidual alkaline phosphatase was studied in adrenalectomized (day 1) and ovariectomized (day 1) rats after uterine traumatization on day 4 of pseudopregnancy. Enzyme activity w…

SUMMARY Incidence and patterns of mitoses and histochemical localization of alkaline phosphatase (APase) and adenosine triphosphatase (ATPase) were studied from days 5 to 20 in pseudopregnant mice in which deciduomata had been induced in th…

SUMMARY 1. Furazolidone (0·75 g/kg) will interrupt pregnancy in mice. 2. Foetal tissue is particularly sensitive to the drug at the time of or before implantation of the ovum. 3. Intra-amniotic injection of furazolidone in rabbits causes fo…