Frontiers in neurology

BACKGROUND: Cognitive fatigability (CF), the decline in performance following sustained cognitive effort, remains less understood in people with multiple sclerosis (PwMS) than subjective fatigue, and no behavioral interventions have yet spe…

The comorbidity between endometriosis and migraine has long been recognized clinically, yet a unifying pathophysiological explanation has remained elusive. Traditional models, centered on hormonal fluctuations or secondary inflammation are …

BACKGROUND: Migraine is a leading cause of disability worldwide, yet national-level epidemiological data are often lacking, hindering public health planning. This study aimed to provide the first comprehensive, population-based assessment o…

BACKGROUND: Migraine is a familial, episodic disorder characterized by complex sensory processing dysfunction, with headache serving as its hallmark feature. While numerous risk factors have been proposed, the causal nature of these associa…

Chronic pain is a multidimensional condition shaped by sex-specific biological and sociocultural factors, leading to distinct vulnerabilities, mechanisms, and treatment experiences in men and women. While women consistently exhibit lower pa…

INTRODUCTION: Irritable bowel syndrome with constipation (IBS-C) is a common functional gastrointestinal disorder characterized by constipation, abdominal discomfort, and a substantial impact on patients' quality of life. While acupuncture …

Neuropathic pain causes plasticity in the nervous system, which is often associated with altered protein synthesis. Proteins are the key executors of cellular functions, and their alteration is closely related to the occurrence of neuropath…

BACKGROUND: Adenomyosis is frequently associated with abnormal uterine bleeding (AUB) and anemia. In the setting of arterial stenosis or hypercoagulability, AUB may precipitate ischemic stroke. However, the optimal management strategy remai…

INTRODUCTION: Persistent postural-perceptual dizziness (PPPD) is a chronic neuro-otologic disorder characterized by vestibular symptoms such as dizziness, unsteadiness, or non-spinning vertigo. Its pathophysiology is presumed to involve sen…

INTRODUCTION: Anti-sulfatide antibodies are key biomarkers for the diagnosis of Guillain-Barré syndrome (GBS). However, case reports on anti-sulfatide antibody-related GBS are rare, particularly for atypical cases. CASE DESCRIPTION CASE 1:…

INTRODUCTION: Previous studies have suggested an association between blood inflammation-related factors and postherpetic neuralgia. However, the causal relationship between blood inflammation-related factors and postherpetic neuralgia remai…

BACKGROUND: Recent years, the use of optical molecular imaging (OMI) techniques guided nerve imaging has made significant progress. However, a comprehensive bibliometric analysis in this field is currently lacking. In this study, we aim to …

Integrated fetal, neonatal, and pediatric training constitute an interdisciplinary fetal-neonatal neurology (FNN) program. A dynamic neural exposome concept strengthens curriculum content. Trainees participate in mentoring committee selecti…

BACKGROUND: Many patients experience persistent symptoms after COVID-19, a syndrome referred to as Long COVID (LC). The goal of this study was to identify novel new or worsening comorbidities self-reported in patients with LC. METHODS: Pat…

BACKGROUND: Drawing on the principles of wrist-ankle acupuncture (WAA), our research team has developed a portable device for WAA point compression, termed the acupressure wrist-ankle strap (AWA). The current study aims to evaluate the effi…

INTRODUCTION: Chronic pain is a public health concern throughout the world. Ascertaining and managing its risk factors helps develop well-directed treatment plans and prevention strategies. Phthalates (PAEs) exposure leads to various health…

The gene that codes for the close homolog of L1 (CHL1 gene) is located in the 3p26.3 cytogenetic band in the distal portion of the 3p chromosome. This gene is highly expressed in the central nervous system and plays an important role in bra…

Although non-invasive and minimally invasive aesthetic procedures increasingly dominate the cosmetic market, traditional plastic surgery remains the most effective improvement method. One of the most common complications in plastic surgery,…

BACKGROUND: Cervicogenic dizziness is a clinical syndrome characterized by neck pain and dizziness. Recent evidence suggested that self-exercise could improve a patient's symptoms. The objective of this study was to evaluate the efficacy of…

A pulmonary arteriovenous fistula (PAVM) is an abnormal blood vessel that creates a direct connection between a pulmonary artery and its tributary vein bypassing capillary filter, establishing as a consequence of a low-resistance right-to-l…

ObjectiveTo determine the concentrations of four neuroprotein biomarkers and 68 miRNAs in neonates with low cord pH and/or mild hypoxic-ischemic encephalopathy (HIE).Study designA prospective cohort study enrolled neonates with low cord pH …

Ischemic stroke (IS) is a severe disease with a high disability, recurrence, and mortality rates. Autophagy, a highly conserved process that degrades damaged or aging organelles and excess cellular components to maintain homeostasis, is act…

Several studies focused on the role of vitamin D (vitD) in pain chronification. This study focused on vitD level and pain chronification and extension in headache disorders. Eighty patients with primary headache underwent neurological exami…

Objective: Iron deficiency anemia (IDA) is a well-known cause of secondary restless legs syndrome (RLS). Iron deficiency without anemia (IDNA) is insidious, and its association with RLS is less evaluated. We investigate prevalence and featu…