Molecular biology reports

Despite major advances in medicine, cancer treatment remains a considerable challenge. The rising incidence of new cases and the frequent resistance to cytostatics suggest that standard therapies may be insufficient. This highlights the nee…

BACKGROUND: Endometriosis is a chronic, estrogen-dependent inflammatory disease characterized by the presence of endometrial-like tissue outside the uterine cavity and is associated with pain, infertility, and impaired quality of life. Alth…

Ovarian cancer (OC) remains difficult to detect at an early stage, and current screening approaches using CA125 and transvaginal ultrasonography have not demonstrated sufficient benefit for population screening. DNA methylation is a promisi…

BACKGROUND: Endometriosis (EMS) is a chronic inflammatory disorder involving ectopic endometrial tissue growth. This study investigated IL-33, CD1c+ dendritic cells (DCs) and their co-stimulatory molecules (CD40, CD80, CD86), and IL-17 A in…

BACKGROUND: Endometriosis (EMs) is a chronic enigmatic gynecological disorder which pathogenesis have not been fully elucidated. Exosomes have been proven to participate in endometriosis. However, the role of exosomes in the pathogenesis of…

Polycystic ovary syndrome (PCOS) and endometriosis are prevalent gynecological disorders associated with chronic inflammation, oxidative stress, hormonal dysregulation, and impaired fertility. Current treatments primarily focus on symptom m…

BACKGROUND: Endometriosis (EMs) is characterized by chronic inflammation, recurrent bleeding, oxidative stress, and disrupted local iron homeostasis. Although macrophages are important components of the immune microenvironment in EMs, their…

BACKGROUND: Pyroptosis has been reported to occur in several diseases, such as atherosclerosis, nonalcoholic steatohepatitis, and endometriosis. Although fucoxanthin has several biological properties (particularly anti-inflammatory properti…

BACKGROUND: Endometriosis (EMS) is an oestrogen-dependent chronic inflammatory disease that primarily manifests as chronic pelvic pain and infertility. EMS-associated infertility is closely linked to diminished ovarian function and oocyte q…

BACKGROUND: Human endometrial stromal cells (hEnSCs) are central to female fertility. This study investigated the cellular and molecular landscape of hEnSCs and identified inter-individual variations that may influence reproductive potentia…

Endometriosis is a chronic gynaecological disorder characterized by ectopic endometrial growth, inflammation, pain, and infertility. Current therapies, largely hormonal and surgical, have limited efficacy and compromise fertility, underscor…

The MYC family has been the subject of extensive research in the field of cancer, yet the mechanisms by which these factors operate in the context of endometriosis remain unclear. Considering the existing studies on the MYC family and disea…

Endometriosis is a challenging gynaecological condition that can lead to infertility. This unique narrative review summarises the impact of endometriosis, focusing on oocyte quality, its subcellular and molecular mechanisms, clinical effect…

Ovarian cancer remains one of the most lethal gynecological malignancies worldwide due to late-stage diagnosis, poor prognosis, and frequent chemoresistance. The limited sensitivity and specificity of current diagnostic approaches, particul…

Adenomyosis (ADM) is a common gynecological condition defined by the atypical invasion of endometrial-like structures, including glands and stroma, into the myometrium. ADM has been attributed to many etiologies, with substantial evidence s…

EMs is a chronic, estrogen-dependent systemic inflammatory disorder defined by the ectopic implantation of endometrial glands and stroma and is frequently associated with dysmenorrhea, chronic pelvic pain, infertility, and substantial impai…

Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation and the accumulation of reactive oxygen species (ROS), distinguishing it from apoptosis, necroptosis, and pyroptosis, and playing a vi…

BACKGROUND: Extracellular vesicles (EVs), including exosomes, play pivotal roles in the pathogenesis, diagnosis, and treatment of endometriosis. These nanosized vesicles carry bioactive molecules such as microRNAs (miRNAs), long noncoding R…

BACKGROUND: Pathogenic variants in BRCA1 and BRCA2 are well known drivers of homologous recombination deficiency in ovarian carcinoma. Somatic BRCA mutations are observed in a minority of ovarian cancers. The co-occurrence of both BRCA1 and…

OBJECTIVE: Integrin αVβ3 has been implicated in oocyte membrane organization and sperm-oocyte interaction. This study investigated the effects of vitrification on post-warming survival and on the surface expression of integrin αV and β3 sub…

Female infertility is a complex and multifactorial disease affecting millions of women worldwide, wherein oxidative stress and inflammation play major roles in its pathophysiology. Flavonoids, a class of polyphenolic compounds derived from …

INTRODUCTION: Endometriosis is a chronic inflammatory disorder marked by the ectopic growth of endometrial-like tissue, affecting 10–15% of women of reproductive age. Pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) drive inflammation and di…

OBJECTIVE: Endometriosis is a chronic inflammatory disorder characterized by ectopic growth of endometrial-like tissue. Cytokines play pivotal roles in coordinating tissue inflammation and immune responses. Therefore, some pro- and anti-inf…

As a gynecological disease, endometriosis is a disease in which pain and inflammation are important parts. Endometriosis is a chronic, estrogen-related situation with a multifactorial etiology that remains incompletely understood. Endometri…