Biology direct

· 4 papers in corpus
lab-animal 2026
O-GlcNAcylation regulates endometrial decidualization through dual mechanisms: PI3K-AKT axis-mediated phosphorylation and direct modification of FOXO1
doi:10.1186/s13062-026-00750-2 ·PMID:41821103

BACKGROUND: Steroid hormone-driven endometrial decidualization involves the differentiation of endometrial stromal cells into decidual cells, which form the decidua for blastocyst implantation. This process is a prerequisite for successful …

lab-animal 2024
LncRNA NORFA promotes the synthesis of estradiol and inhibits the apoptosis of sow ovarian granulosa cells through SF-1/CYP11A1 axis
doi:10.1186/s13062-024-00563-1 ·PMID:39523350

BACKGROUND: Biosynthesis of 17β-estradiol (E2) is a crucial ovarian function in mammals, which is essential for follicular development and pregnancy outcome. Exploring the epigenetic regulation of E2 synthesis is beneficial for maintaining …

lab-animal 2024
Single-cell transcriptomic profiling unveils insights into ovarian fibrosis in obese mice
doi:10.1186/s13062-024-00496-9 ·PMID:38956667

BACKGROUND: Adiposity profoundly impacts reproductive health in both humans and animals. However, the precise subpopulations contributing to infertility under obese conditions remain elusive. RESULTS: In this study, we established an obese…

lab-animal 2023
Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by alleviating pyroptosis in vitro and in vivo rat models.
doi:10.1186/s13062-023-00380-y ·PMID:37165439

ObjectiveHypertriglyceridemia (HTG) is one of the common causes of acute pancreatitis (AP). Hyperlipidemic acute pancreatitis (HTG-AP) is associated with higher mortality owing to its tendency for greater severity and rapid progression. The…