International journal of women's health

PURPOSE: Relugolix is an oral, non-peptide gonadotropin-releasing hormone receptor antagonist administered as once-daily combination therapy (relugolix-CT; 40 mg relugolix, 1 mg estradiol, 0.5 mg norethindrone acetate) to reduce endometrios…

PURPOSE: Women's health research remains under-resourced, underprioritized, and narrowly defined. Across the life course, women experience distinct health needs with significant implications for health and wellbeing, yet persistent gaps in …

PURPOSE: Adenomyosis (AM) and endometrial polyps (EPs) are frequently identified in women evaluated for abnormal uterine bleeding, pelvic pain, infertility, and peri- or postmenopausal symptoms. However, coexistence estimates arise from het…

OBJECTIVE: Deep infiltrating endometriosis (DIE) is a severe endometriosis phenotype. This study aimed to develop and internally validate a machine learning-based predictive model for DIE using retrospective clinical data from a single cent…

BACKGROUND: Recurrence of endometrioma and dysmenorrhea after surgery remains a major clinical challenge. Identifying reliable risk factors is essential to optimize individualized treatment and follow-up strategies. However, large-scale dat…

Endometriosis is a common gynecologic disorder that can be considered in two major categories based on whether the endometrium invades the myometrium: adenomyosis, in which the endometrial glands and mesenchyme migrate into the myometrium, …

PURPOSE: This study aimed to systematically assess the genetic comorbidity of endometriosis (EM) and its subtypes with menstrual-cycle-related traits, and to identify shared genetic mechanisms and key regulatory pathways underlying their as…

BACKGROUND: Mature cystic teratoma (MCT) is a common benign ovarian germ cell tumor; however, its occurrence in the fallopian tube or paratubal region is exceedingly rare. Preoperative diagnosis is challenging due to nonspecific clinical an…

PURPOSE: Endometriosis causes pelvic pain, dysmenorrhea (DYS), dyspareunia, and fertility issues. Linustedastat (OG-6219) is an oral, selective inhibitor of 17β-hydroxysteroid dehydrogenase type 1 (HSD17β1), an enzyme involved in local estr…

Cardiovascular disease (CVD) remains a significant cause of morbidity and mortality amongst women. While our general understanding of evaluation and treatment of CVD has greatly improved over the past decades, there is a gap in the knowledg…

PURPOSE: Adenomyosis severity assessment remains challenging due to the lack of objective imaging parameters associated with underlying tissue characteristics. This study aimed to investigate the association between 3D transvaginal ultrasou…

PURPOSE: Endometriosis is one of the main reproductive issues that the modifiable risk factors is still the main research focus. It is still unclear how various adiposity affect the onset and spread of endometriosis because some studies hav…

OBJECTIVE: Infertility affects approximately 15% of couples worldwide and represents a significant global health burden with profound psychological, social, and economic consequences. Nearly 15% of couples globally experience infertility wh…

BackgroundMetabolic abnormalities have been increasingly implicated in female reproductive dysfunction. The HbA1c-to-HDL-C ratio may reflect the combined burden of chronic glycemic exposure and lipid-related metabolic status; however, its r…

BACKGROUND: Smoking and alcohol consumption have been consistently associated with adverse female reproductive outcomes; however, whether these associations reflect causal effects or are mediated by specific circulating metabolites remains …

PURPOSE: Adolescent endometriosis (EMs) imposes substantial physical and psychological burdens on young female patients, and adaptive coping strategies are vital for their health management. This study aimed to explore the latent classes of…

Ovarian cysts are common benign gynecologic tumors in women of reproductive age. Laparoscopic ovarian cystectomy (LOC) is generally preferred when fertility preservation is intended. Large cysts, or those with intraoperative frozen-section …

Bicornuate uterus is an uncommon congenital Müllerian duct anomaly resulting from incomplete fusion of the paramesonephric ducts and is associated with adverse reproductive outcomes, including recurrent pregnancy loss, preterm birth, and ma…

OBJECTIVE: Polyunsaturated fatty acids (PUFAs) are hypothesized to modulate female reproductive endocrine disorders, yet their causal relationships remain elusive. We employed Mendelian randomization (MR) to investigate bidirectional causal…

BACKGROUND: Endometriosis is a chronic estrogen-dependent inflammatory disease that shares epidemiological and pathological features with endometrial cancer. However, the cellular and genetic mechanisms underlying this association remain un…

BACKGROUND: Female reproductive system diseases, including malignant tumors such as breast, ovarian, and uterine cancers, and non-neoplastic disorders such as uterine fibroids, endometriosis, polycystic ovary syndrome (PCOS), infertility, a…

INTRODUCTION: This study examines the burden of six gynecological system diseases (uterine fibroids, polycystic ovarian syndrome, endometriosis, cervical cancer, ovarian cancer, and uterine cancer) in Chinese women aged 15-49 years from 199…

BACKGROUND: Hormonal contraceptives are widely used, however, their safety among women with underlying medical conditions, particularly cardiometabolic disorders such as hypertension, diabetes mellitus, and obesity, remains a key clinical c…

PURPOSE: Previous studies suggested that irregular sleep-wake rhythms increased the risk of endometriosis. Mechanistically, sleep pattern dysregulation may promote the pathogenesis of endometriosis via neuroendocrine disturbances. However, …