Molecular therapy : the journal of the American Society of Gene Therapy

Mol Ther · ISSN (print) 1525-0016 · 6 papers in corpus
nonrandomized-trial 2026
doi:10.1016/j.ymthe.2025.09.035 ·PMID:40988336

Clinical application of mesenchymal stem cells for endometrial repair has been hampered by variability in cell quality, large-scale production, and uncertainty regarding the optimal delivery route. In this study, we investigated the therape…

review 2023
doi:10.1016/j.ymthe.2022.12.005 ·PMID:36518080

Inflammation, a hallmark of cancer, has been associated with tumor progression, transition into malignant phenotype and efficacy of the chemotherapeutic agents in cancer. Chronic inflammation provides a favorable environment for tumorigenes…

lab-animal 2020
doi:10.1016/j.ymthe.2020.02.014 ·PMID:32112713

Mesenchymal stem cell (MSC) therapies for wound healing are often compromised due to low recruitment and engraftment of transplanted cells, as well as delayed differentiation into cell lineages for skin regeneration. An increased expression…

lab-animal 2020
doi:10.1016/j.ymthe.2019.11.024 ·PMID:31866117

Local endometrial stem cells play an important role in regulating endometrial thickness, which is an essential factor for successful embryo implantation and pregnancy outcomes. Importantly, defects in endometrial stem cell function can be r…

other 2020
doi:10.1016/j.ymthe.2020.01.008 ·PMID:31951829
lab-animal 2004
doi:10.1016/j.ymthe.2003.12.012 ·PMID:15093184

Endometriosis is a prevalent disease characterized by the estrogen-dependent ectopic growth of endometrial tissue. Most of the current medical therapies consist in inducing a hypoestrogenic state in patients, but these treatments are associ…