Xinli Hu — Endo Lab

review 2026

Pathological roles of prolactin signaling in gynecologic and female-predominant diseases and prospects for targeted therapy

·doi:10.1360/csb-2025-5885

Prolactin (PRL) was first identified as a pituitary hormone essential for lactation, but it is now recognized as a pleiotropic regulator of endocrine balance, metabolism, immune function, and tissue remodeling. PRL is secreted systemically …

2025

Safety and efficacy of subcutaneous injection with HMI-115 versus placebo in endometriosis-associated pain in premenopausal women: a multicentre, double-blind, randomised, proof-of-concept phase 2 trial

·doi:10.1016/j.lanogw.2025.100032

lab-animal 2025

Single-cell RNA sequencing identifies the prolactin receptor as a therapeutic target in adenomyosis

Signal transduction and targeted therapy ·doi:10.1038/s41392-025-02339-z

Adenomyosis is a complex gynecological disease characterized by endometrial tissue invasion into the myometrium. Current interventions, such as hormonal therapy or hysterectomy, are associated with significant side effects and compromise fe…

other 2023

FinnGen provides genetic insights from a well-phenotyped isolated population

Nature ·doi:10.1038/s41586-022-05473-8

Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%). These variants survived the founding …