Russell R. Broaddus

Endometrioid endometrial cancer (EEC) is the most prevalent gynecological malignancy. While early-stage EEC typically carries a favorable prognosis, late-stage EEC shows significantly poorer outcomes, with a five-year survival rate of only …

Endometrial cancer (EC) is a growing public health concern. This secondary data study of a case series leveraged existing samples and data to explore the potential link between exposure to heavy metals/essential elements and stage of EC. We…

PDF file - 387K, Three-lineage differentiation of O-ASC.

PDF file - 387K, Three-lineage differentiation of O-ASC.

PDF file - 678K, O-ASC do not co-localize with CD31 positive endothelial cells.

PDF file - 678K, O-ASC do not co-localize with CD31 positive endothelial cells.

PDF file - 202K, Quantification of histological and immunofluorescence tissue analysis.

PDF file - 202K, Quantification of histological and immunofluorescence tissue analysis.

PDF file - 139K, Endometrial Hec1a cancer cell proliferation in co-culture with OSC, MSC, ASC and WI38 fibroblasts.

PDF file - 139K, Endometrial Hec1a cancer cell proliferation in co-culture with OSC, MSC, ASC and WI38 fibroblasts.

PDF file - 99K, Migration of stromal cells in response to Hec1a conditioned media.

PDF file - 99K, Migration of stromal cells in response to Hec1a conditioned media.

PDF file - 281K, Hec1a secrete IL8 and CXCL1.

PDF file - 281K, Hec1a secrete IL8 and CXCL1.

PDF file - 1.0MB, Expression of IL8 / CXCL1 receptors in mesenchymal cells.

PDF file - 1.0MB, Expression of IL8 / CXCL1 receptors in mesenchymal cells.

Endometrial cancer remains the most common gynecological malignancy in the United States. While the loss of the tumor suppressor, PTEN (phosphatase and tensin homolog), is well studied in endometrial cancer, recent studies suggest that DICE…

There is currently no blood-based marker in routine use for endometrial cancer patients. Such a marker could potentially be used for early detection, but it could also help to track tumor recurrence following hysterectomy. This is important…

BACKGROUND: Aberrant hyperactivation of epithelial proliferation, AKT signaling, and association with unopposed estrogen (E2) exposure is the most common endometrial cancer dysfunction. In the normal uterus, progesterone (P4) inhibits proli…

Over the past two decades, 33 cases of colonic adenocarcinomas have been diagnosed in rhesus macaques (Macaca mulatta) at the nonhuman primate colony of the Keeling Center for Comparative Medicine and Research at The University of Texas MD …

PIK3R1 (p85α regulatory subunit of PI3K) is frequently mutated across cancer lineages. Herein, we demonstrate that the most common recurrent PIK3R1 mutation PIK3R1(R348∗) and a nearby mutation PIK3R1(L370fs), in contrast to wild-type and mu…

Endometrial cancer is preceded by endometrial hyperplasia, unopposed estrogen exposure, and genetic alterations, but the precise causes of endometrial cancer remain uncertain. Mig-6, mainly known as a negative regulator of the EGF receptor,…

Adenomyosis is defined by the presence of endometrial glands and stroma within the myometrium. Despite its frequent occurrence, the precise aetiology and physiopathology of adenomyosis is still unknown. WNT/β-catenin signalling molecules ar…

Conditional ablation of Indian hedgehog (Ihh) in the murine uterus results in mice that are sterile because of defects in embryo implantation. We performed microarray analysis on these mice at the time point at which the Ihh target genes ar…

Abstract Adenomyosis is a common gynecological disorder defined by the presence of endometrial glands and stroma within the myometrium. Despite its frequent occurrence, the precise etiology of adenomyosis is still unknown, although it has o…