Maria Vertzoni

ORCID: 0000-0003-4463-2459 · 4 papers in corpus
review 2023
Challenges in Permeability Assessment for Oral Drug Product Development
Pharmaceutics ·doi:10.3390/pharmaceutics15102397

Drug permeation across the intestinal epithelium is a prerequisite for successful oral drug delivery. The increased interest in oral administration of peptides, as well as poorly soluble and poorly permeable compounds such as drugs for targ…

lab-animal 2021
In Vitro Simulation of the Environment in the Upper Gastrointestinal Lumen After Drug Administration in the Fed State Using the TIM-1 System and Comparison With Luminal Data in Adults
Journal of pharmaceutical sciences ·doi:10.1016/j.xphs.2021.10.010

We evaluated the environment in TIM-1 luminal compartments using paracetamol and danazol solutions and suspensions and the fed state configuration. Data were compared with recently published data in healthy adults. TIM-1 experiments were pe…

rct 2020
Disposition of two highly permeable drugs in the upper gastrointestinal lumen of healthy adults after a standard high-calorie, high-fat meal
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences ·doi:10.1016/j.ejps.2020.105351

OBJECTIVES: To quantify the presence of two model highly permeable drugs, paracetamol and danazol, in the upper gastrointestinal lumen under conditions simulating the situation after disintegration of immediate release dosage forms administ…

other 2012
Luminal lipid phases after administration of a triglyceride solution of danazol in the fed state and their contribution to the flux of danazol across Caco-2 cell monolayers
Molecular pharmaceutics ·doi:10.1021/mp200479f

The first aim of this study was to characterize the luminal contents and their micellar phase after the administration of a heterogeneous liquid meal to healthy adults. The second aim was to evaluate the impact of micellar lipids and coarse…