Shizuo Akira

ORCID: 0000-0001-7602-9617 · 3 papers in corpus
lab-animal 2022
The Role of mPGES-1 in Promoting Granulation Tissue Angiogenesis Through Regulatory T-cell Accumulation
In vivo (Athens, Greece) ·doi:10.21873/invivo.12932

BACKGROUND/AIM: Microsomal prostaglandin E synthase-1 (mPGES-1) is an enzyme, which catalyzes the final step of prostaglandin E2 (PGE2) synthesis. PGE2 in involved in wound-induced angiogenesis. Regulatory T cells (Tregs) regulate not only …

lab-animal 2013
Signal transducer and activator of transcription-3 (Stat3) plays a critical role in implantation via progesterone receptor in uterus
FASEB journal : official publication of the Federation of American Societies for Experimental Biology ·doi:10.1096/fj.12-225664

Recent studies have shown that activation of the signal transducer and activator of transcription-3 (Stat3) is required for decidualization, interacting with progesterone receptor (PR) in uterus. Based on previous reports, we hypothesized t…

lab-animal 2010
The inducible prostaglandin E synthase mPGES-1 regulates growth of endometrial tissues and angiogenesis in a mouse implantation model
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie ·doi:10.1016/j.biopha.2010.12.008

Endometriosis is one of the most common gynecological diseases in women of reproductive age. Although cyclooxygenase (COX)-2 inhibitors are effective in the treatment of endometriosis, the adverse cardiovascular effects associated with thes…