Brigitte Vollmar

ORCID: 0000-0002-2403-9597 · 9 papers in corpus
lab-animal 2020
Analysis of Animal Well-Being When Supplementing Drinking Water with Tramadol or Metamizole during Chronic Pancreatitis
Animals : an open access journal from MDPI ·doi:10.3390/ani10122306

Pain management during in vivo experiments is an animal welfare concern and is in many countries also legally required. In this study, we evaluated C57Bl/6J mice when 3 g/L metamizole or 1 g/L tramadol was provided via drinking water, befor…

lab-animal 2018
Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells
World journal of gastroenterology ·doi:10.3748/wjg.v24.i28.3120

AIM: To evaluate the influence of hyperglycemia on the progression of autoimmune pancreatitis. METHODS: We induced hyperglycemia by repetitive intraperitoneal (ip) injection of 50 mg/kg streptozotocin in MRL/MpJ mice, which develop autoimm…

lab-animal 2015
regression of endometriotic lesions

Epigallocatechin-3-gallate inhibits estrogen-induced activation of endometrial cells in vitro and causes

lab-animal 2010
Genistein does not affect vascularization and blood perfusion of endometriotic lesions and ovarian follicles in dorsal skinfold chambers of Syrian golden hamsters
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719110364417

Genistein has previously been shown to cause regression of endometriotic lesions. In the current study, we investigated whether this observation is due to the antiangiogenic activity of genistein. Endometrial fragments and ovarian follicles…

lab-animal 2008
Epigallocatechin-3-gallate inhibits estrogen-induced activation of endometrial cells in vitro and causes regression of endometriotic lesions in vivo
Human Reproduction ·doi:10.1093/humrep/den245

BACKGROUND: Epigallocatechin-3-gallate (EGCG), the major component of green tea, is a pleiotropic substance, which may inhibit tumor growth via multiple intracellular signaling pathways. Herein, we studied whether EGCG may also be effective…

lab-animal 2006
Rapamycin induces regression of endometriotic lesions by inhibiting neovascularization and cell proliferation
British journal of pharmacology ·doi:10.1038/sj.bjp.0706857

BACKGROUND AND PURPOSE: Rapamycin is a widely used drug with antifungal, immunosuppressant and antiangiogenic effects. Herein, we studied whether immunosuppressive doses of rapamycin are capable of influencing endometriotic lesions. EXPERI…

lab-animal 2006
Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2006.05.068

OBJECTIVE: To investigate the effects of selective cyclo-oxygenase-2 (COX-2) inhibition on the angiogenesis and proliferation of endometrial grafts. DESIGN: Intravital fluorescence microscopic study. SETTING: Institute for Clinical and Ex…

lab-animal 2005
Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions
Human Reproduction ·doi:10.1093/humrep/dei308

BACKGROUND: Angiogenesis represents the crucial step in the pathogenesis of endometriosis, because endometriotic lesions require neovascularization to establish, proliferate and invade inside the peritoneal cavity. To elucidate the role of …

lab-animal 2005
In vivo analysis of angiogenesis in endometriosis-like lesions by intravital fluorescence microscopy
Fertility and sterility ·doi:10.1016/j.fertnstert.2005.05.010

OBJECTIVE: To establish a novel endometriosis model that allows for repetitive in vivo analyses of angiogenesis in ectopic endometrial tissue. DESIGN: Intravital fluorescence microscopic study. SETTING: Institute for Clinical and Experime…