Kay Elder — Endo Lab

review 2022

Folic Acid, Folinic Acid, 5 Methyl TetraHydroFolate Supplementation for Mutations That Affect Epigenesis through the Folate and One-Carbon Cycles

Biomolecules ·doi:10.3390/biom12020197

Methylation is an essential biochemical mechanism that is central to the transmission of life, and crucially responsible for regulating gametogenesis and continued embryo development. The methylation of DNA and histones drives cell division…

lab-animal 2021

Image depository for Communications Biology paper 'Menstrual flow as a non-invasive source of endometrial organoids'

·doi:10.17863/cam.68319

This depository contains all microscopy images presented in ‘Menstrual flow as a non-invasive source of endometrial organoids’ paper accepted at Communications Biology; Tereza Cindrova-Davies et al. present a method for deriving endometrial…

other 2021

Menstrual flow as a non-invasive source of endometrial organoids

Communications biology ·doi:10.1038/s42003-021-02194-y

Assessment of the endometrium often necessitates a biopsy, which currently involves an invasive, transcervical procedure. Here, we present an alternative technique based on deriving organoids from menstrual flow. We demonstrate that organoi…

review 2020

Methylation: An Ineluctable Biochemical and Physiological Process Essential to the Transmission of Life

International journal of molecular sciences ·doi:10.3390/ijms21239311

Methylation is a universal biochemical process which covalently adds methyl groups to a variety of molecular targets. It plays a critical role in two major global regulatory mechanisms, epigenetic modifications and imprinting, via methyl ta…

review 2016

Oxidative stress and alterations in DNA methylation: two sides of the same coin in reproduction

Reproductive BioMedicine Online ·doi:10.1016/j.rbmo.2016.09.006

The negative effect of oxidative stress on the human reproductive process is no longer a matter for debate. Oxidative stress affects female and male gametes and the developmental capacity of embryos. Its effect can continue through late sta…

other 2015

Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect

eLife ·doi:10.7554/elife.11389

Aneuploidy in human eggs is the leading cause of pregnancy loss and Down's syndrome. Aneuploid eggs result from chromosome segregation errors when an egg develops from a progenitor cell, called an oocyte. The mechanisms that lead to an incr…

other 2015

The Oldham Notebooks: an analysis of the development of IVF 1969-1978. I. Introduction, materials and methods

Reproductive biomedicine & society online ·doi:10.1016/j.rbms.2015.04.001

In this introductory paper, we describe the primary source material studied in this Symposium, namely a set of 21 notebooks and 571 pages of loose sheets and scraps of paper, which, on cross-referencing, have allowed us to reconstruct the s…

2014

1° infertility Diagnosis: endometriosis + male factor

·doi:10.1017/9780511791543.052