John A. Lucas — Endo Lab

other 2012

Dietary fish oil supplementation inhibits formation of endometriosis-associated adhesions in a chimeric mouse model

Fertility and sterility ·doi:10.1016/j.fertnstert.2012.10.007

OBJECTIVE: To examine whether dietary fish oil supplementation reduces development of spontaneous endometriosis-associated adhesions using an established model. DESIGN: Laboratory-based study. SETTING: Medical center research laboratory. …

lab-animal 2012

The Role of Endocrine Disruptors in the Epigenetics of Reproductive Disease and Dysfunction: Potential Relevance to Humans

Current Obstetrics and Gynecology Reports ·doi:10.1007/s13669-012-0014-7

In a murine model, we have linked early life toxicant exposure to reduced uterine sensitivity to progesterone, a phenotype we had previously associated with inflammation in endometriosis patients. Subsequent studies revealed that developmen…

review 2011

Immune interactions in endometriosis

Expert review of clinical immunology ·doi:10.1586/eci.11.53

Endometriosis is a common, complex gynecologic disorder characterized by the presence of endometrial glands and stroma at extrauterine (ectopic) sites. In women who develop this disease, alterations in specific biological processes involvin…

lab-animal 2011

Preconception omega-3 fatty acid supplementation of adult male mice with a history of developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure prevents preterm birth in unexposed female partners

Reproduction (Cambridge, England) ·doi:10.1530/rep-11-0070

We have recently reported that adult male C57BL/6 mice exposed in utero to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) confer an increased risk of preterm birth (PTB) to unexposed females. Risk of PTB was coinciden…