Stevens Brentjens LBPM

observational 2026

Endometrial Metabolism of 17β-Estradiol during the Window of Implantation in Women with Recurrent Implantation Failure

Gynecologic and obstetric investigation ·doi:10.1159/000546442

UNLABELLED: Objectives: Alterations in 17β-estradiol metabolism are known to potentially impair endometrial receptivity. Previous pioneering studies have investigated the role of endometrial steroid metabolism by determining steroid hormone…

observational 2024

Pregnancy rate and time to pregnancy after recurrent implantation failure (RIF)-a prospective cohort follow-up study

Journal of assisted reproduction and genetics ·doi:10.1007/s10815-024-03257-9

PURPOSE: The goal of this study was to determine ongoing pregnancy rate, time to pregnancy and embryo transfers to pregnancy within a cohort of patients with recurrent implantation failure (RIF). METHODS: IVF patients with RIF were include…

observational 2023

Local production of 17β-oestradiol in the endometrium during the implantation window: a pilot study

Reproduction & fertility ·doi:10.1530/raf-23-0065

ABSTRACT: Sex steroids are converted to bioactive metabolites and vice versa by endometrial steroid-metabolising enzymes. Studies indicate that alterations in this metabolism might affect endometrial receptivity. This pilot study determined…

other 2022

Endometrial factors in the implantation failure spectrum: protocol of a MUltidisciplinary observational cohort study in women with Repeated Implantation failure and recurrent Miscarriage (MURIM Study)

BMJ open ·doi:10.1136/bmjopen-2021-056714

INTRODUCTION: Women with repeated implantation failure (RIF) and unexplained recurrent miscarriage (RM) are proposed to be at opposite ends of the implantation spectrum, with RM representing an overly receptive endometrium (implantation of …