Makoto Orisaka

BACKGROUND: Endometriosis is a chronic, estrogen-dependent inflammatory disorder and a leading cause of female infertility. Ovarian endometriomas, a common manifestation of endometriosis, are commonly associated with diminished ovarian func…

BACKGROUND: Ovarian autoamputation is a rare consequence of adnexal torsion. Preoperative diagnosis is challenging, and ovarian and tubal function on the affected side is rarely preserved once autoamputation has occurred. CASE: A 29-year-o…

BACKGROUND: Chronic low-grade inflammation is increasingly recognized as a contributing factor to female infertility. Elevated levels of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 are observed in ovarian conditions including …

Vaginal cuff dehiscence (VCD) is a rare complication of total laparoscopic hysterectomy (TLH); the incidence rate has been reported to be 1.27%. However, a definitive treatment strategy has not yet been established. To our knowledge, we rep…

BACKGROUND Spontaneous hemoperitoneum in pregnancy (SHiP), defined as nontraumatic, acute intra-abdominal bleeding during pregnancy or the postpartum period, is a serious life-threatening complication to mother and child. Endometriosis is a…

The ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and aging, may compromise the ovarian microenvironment, follicular de…

Herlyn-Werner-Wunderlich syndrome (HWWs) is a rare congenital malformation that involves uterus dideslphys, obstructed hemivagina and ipsilateral renal agenesis. The obstructed vagina affects menstrual flow and causes related clinical featu…

Reduced fertility is one of the main long-term consequences of chemotherapy given for lymphoma, leukemia, and other malignancies in young women. We examined with a female rat model whether and how dienogest, a fourth-generation progestin, m…