Zhuang G

ORCID: 0000-0001-8141-5096 · 4 papers in corpus
case-report 2023
APOBEC3B stratifies ovarian clear cell carcinoma with distinct immunophenotype and prognosis
British journal of cancer ·doi:10.1038/s41416-023-02239-5

BACKGROUND: Ovarian clear cell carcinoma (OCCC) is a challenging disease due to its intrinsic chemoresistance. Immunotherapy is an emerging treatment option but currently impeded by insufficient understanding of OCCC immunophenotypes and th…

observational 2023
Development and external validation of nomograms for predicting individual survival in patients with ovarian clear cell carcinoma
Cancer medicine ·doi:10.1002/cam4.5853

PURPOSE: Ovarian clear cell carcinoma (OCCC) is a distinct and highly malignant subtype of ovarian cancer with high individual heterogeneity in survival that requires specific prognostic predictive tools. Thus, this study aimed to construct…

other 2020
Multiregion whole-genome sequencing depicts intratumour heterogeneity and punctuated evolution in ovarian clear cell carcinoma
Journal of medical genetics ·doi:10.1136/jmedgenet-2019-106418

BACKGROUND: Ovarian clear cell carcinoma (OCCC) arises from endometriosis and represents a difficult-to-treat gynaecological malignancy, in part, because its spatial intratumour heterogeneity and temporal evolutionary trajectories have not …

lab-animal 2020
Protein kinase CK2 participates in estrogen-mediated endothelial progenitor cell homing to endometriotic lesions through stromal cells in a stromal cell-derived factor-1- CXCR4-dependent manner
Fertility and sterility ·doi:10.1016/j.fertnstert.2019.12.035

OBJECTIVE: To explore the possible mechanism of protein kinase CK2, which participates in estrogen recruitment of endothelial progenitor cells (EPCs), and its role in the angiogenesis of endometriosis lesions. DESIGN: Laboratory study. SE…