Matthew J. Sikora
ORCID: 0000-0003-2915-7442
· 7 papers in corpus
lab-animal
2025
Abstract Ovarian clear cell carcinoma (OCCC) is an aggressive, endometrial-derived subtype of ovarian cancer (OvCa) which affects young women. Late stage OCCC is resistant to chemotherapy and has the worst outcome compared to other OvCa sub…
lab-animal
2024
BioID setup and proof-of-concept
other
2024
UNLABELLED: Wnt ligand WNT4 is critical in female reproductive tissue development, with WNT4 dysregulation linked to related pathologies including breast cancer (invasive lobular carcinoma, ILC) and gynecologic cancers. WNT4 signaling in th…
review
2021
The WNT family of proteins is crucial in numerous developmental pathways and tissue homeostasis. WNT4, in particular, is uniquely implicated in the development of the female phenotype in the fetus, and in the maintenance of müllerian and re…
lab-animal
2020
Invasive lobular carcinoma of the breast (ILC) is strongly estrogen-driven and represents a unique context for estrogen receptor (ER) signaling. In ILC, ER controls the expression of the Wnt ligand WNT4, which is critical for endocrine resp…
other
2018
To investigate changes in estrogen receptor alpha (ERα) signaling during progression of endometriosis to endometriosis-associated ovarian cancer (EAOC) as a driver of malignant transformation. We procured tissue samples of normal endometriu…
2016