Miyuki Harada

RESEARCH QUESTION: Does adenomyosis increase the risk of thromboembolic events, including both arterial and venous thromboembolism, compared with endometriosis, and what clinical factors may contribute to this association? DESIGN: This ret…

Objective To evaluate the long-term impact of postoperative oral contraceptive (OC) recommendation after laparoscopic cystectomy endometrioma on the incidence of endometrioma recurrence and ovarian cancer development. Material and methods T…

BACKGROUND: We aimed to evaluate the risk of perinatal complications in subsequent pregnancies after different types of myomectomy, viz. open, laparoscopic, or hysteroscopic. Moreover, we investigated whether the time interval from myomecto…

Abstract Objective To evaluate the efficacy of prophylactic antibiotic regimens in preventing pelvic inflammatory disease (PID) after embryo transfer (ET) among patients with endometriosis, a risk factor of PID. Material and methods Th…

Adenomyosis is an intractable gynecological disorder that can give rise to severe pelvic pain, heavy menstrual bleeding, and infertility, predominantly affecting women of reproductive age. The limited efficacy of current pharmacological int…

PURPOSE: Recurrent implantation failure (RIF) is a form of refractory infertility that persists despite assisted reproductive technology. Cine magnetic resonance imaging (cine MRI) enables the visualization of uterine peristalsis; however, …

BACKGROUND: The age-related decline of fertility is caused by a reduction of the ovarian reserve, which is represented by the number and quality of oocytes in the ovaries. Anti-Müllerian hormone (AMH) is considered one of the most useful ma…

Chronic endometritis (CE) and endometrial dysbiosis (ED) are major causes of recurrent implantation failure (RIF). CE is diagnosed via hysteroscopy or the endometrial CD138 test; ED is examined using endometrial microbiome testing with next…

PURPOSE: This study evaluated whether embryo cryopreservation before surgery (ECBS) improves clinical outcomes in in vitro fertilization (IVF) patients with endometrioma. METHODS: This retrospective study included patients aged 28-42 years…

RESEARCH QUESTION: How significant is the impact of dysmenorrhea on work productivity and quality of life (QoL) among Japanese women?. METHODS: This large-scale cross-sectional study was conducted using a web-based self-report questionnair…

Adenomyosis often causes dysmenorrhea in women of reproductive age. Progestins such as levonorgestrel intrauterine system (LNG-IUS) are often used for treatment, but some patients experience progesterone resistance, showing poor treatment r…

Uterine adenomyosis is a common disease in women of reproductive age that causes dysmenorrhea, abnormal uterine bleeding, infertility, and obstetric complications. Rarely, adenomyosis can lead to abscess formation, which is refractory to an…

The follicular microenvironment is crucial for normal ovarian function, and intra-ovarian factors, in coordination with gonadotropins, contribute to its regulation. Recent research has revealed that the accumulation of senescent cells worse…

It is unclear whether clinical background differs between endometriosis in adolescent patients with obstructive Müllerian anomalies and those without anomalies. The aim of the study is to identify the difference in clinical characteristics …

Ulipristal (UPA), a selective progesterone receptor modulator, has both agonistic and antagonistic effects on progesterone receptors. UPA suppresses ovulation by inhibiting the luteinizing hormone (LH) surge from the pituitary gland; howeve…

Abstract Ulipristal (UPA), a selective progesterone receptor modulator, has both agonistic and antagonistic effects on progesterone receptors. UPA suppresses ovulation by inhibiting the luteinizing hormone (LH) surge from the pituitary glan…

BACKGROUND: Adenomyosis is a common gynecological disease in women of reproductive age and causes various symptoms such as dysmenorrhea and heavy menstrual bleeding. However, the influence of pregnancy on the progression of adenomyosis rema…

Abstract Background Previous studies have shown the ovarian carcinoma after laparscopic cystectomy of endometrioma arises through the recurrence of endometrioma. Then it can be assumed that reduction of ovarian endometrioma recurrence throu…

OBJECTIVE: To evaluate the phosphorylation of estrogen receptor α at serine-118 (phospho-ERα S118) in the endometrium, ovarian endometrioma, and deep infiltrating endometriosis (DIE). DESIGN: Experimental study. SETTING: University-affili…

Abstract Background: The purpose of this study was to establish a novel mouse model of adenomyosis suitable for longitudinal and quantitative analyses and perinatal outcome studies. Methods: Using a 30 G needle, the entire ute…

The purpose of this study was to establish a novel mouse model of adenomyosis suitable for longitudinal and quantitative analyses and perinatal outcome studies. Using a 30 G needle, the entire uterine wall of one horn was mechanically punct…

AIM: Endometriosis is linked to asymptomatic atherosclerosis and increases the risk of cardiovascular disease (CVD). Vascular function tests are used to assess atherosclerosis, an important indicator of CVD development. In this study, we ai…

Aim: Endometriosis is linked to asymptomatic atherosclerosis and increases the risk of cardiovascular disease (CVD). Vascular function tests are used to assess atherosclerosis, an important indicator of CVD development. In this study, we ai…

The purpose of this study was to establish a new mouse model of endometriosis that mimics real-world women's health problems, in which women continue to be affected by endometriosis long before they wish to become pregnant, and to evaluate …