Alexander Hein

PURPOSE: In many diseases, it is possible to classify a heterogeneous group into subgroups relative to tumor biology, genetic variations, or clinical and pathological features. No such classification is available for endometriosis. In our r…

Einleitung: Die Endometriose ist mit ihren vielseitigen Erscheinungsformen ein Chamäleon unter den Erkrankungen. Eine eindeutige Ätiologie ist bislang nicht bekannt und die Heterogenität der klinischen Symptomatik erschwert die frühzeitige …

Zielsetzung: Endometriose ist eine heterogene Erkrankung mit unterschiedlichen Erscheinungsformen und Ausprägungsgraden. Bisher existiert jedoch keine etablierte Einteilung in Untergruppen. Ziel dieser Fall-Fall-Studie ist es, eine Populati…

Zielsetzung Endometriose ist eine heterogene Erkrankung mit unterschiedlichen Erscheinungsformen und Ausprägungsgrade. Eine Einteilung in Untergruppen ist bisher nicht bekannt. Ziel dieser Fall-Fall-Studie ist es, eine Population von Endome…

It is known that endometriosis is associated with an increased risk for certain forms of ovarian cancer. However it is unknown, which kind of endometriosis is associated with ovarian cancer and furthermore, if endometriosis is associated wi…

Sowohl für das Ovarialkarzinom als auch für Endometriose sind genetische Varianten als Risikofaktoren validiert. Endometriose ist als Risikofaktor für das klarzellige, das endometrioide und das low grade seröse Ovarialkarzinom beschrieben. …

Abstract Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and…

Several genetic variants have been validated as risk factors for endometriosis, endometrial and ovarian cancer. Endometriosis has also been described as a risk factor for endometrial and ovarian cancer. The aim of the present study was to t…

Disruption in circadian gene expression, whether due to genetic variation or environmental factors (e.g., light at night, shiftwork), is associated with increased incidence of breast, prostate, gastrointestinal and hematologic cancers and g…

Background: No screening programs are available for ovarian or endometrial cancer. One reason for this is the low incidence of the conditions, resulting in low positive predictive values for tests, which are not very specific. One way of ad…

There is no screening program for ovarian or endometrial cancer. One reason for that could be the relatively low incidence with subsequently low positive predictive values for tests with low specifity. One way to address the problem could b…

BACKGROUND: Medical research studies are becoming increasingly important for optimizing the prevention, diagnosis and treatment of illnesses. Participation in research studies can have many benefits for patients. In randomized and controlle…

Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associatio…

Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associatio…

Background: There is no screening program for ovarian or endometrial cancer. One way to address the problem could be the utilization of risk factors to define sub-populations with a higher incidence. Recently, there were hints that endometr…

A missense single-nucleotide polymorphism (SNP) in the immune modulatory gene IL1A has been associated with ovarian cancer risk (rs17561). Although the exact mechanism through which this SNP alters risk of ovarian cancer is not clearly unde…