William B. Schoolcraft

nonrandomized-trial 2025

Prolonged oral GnRH-antagonist administration before euploid embryo transfer in patients with endometriosis: a prospective randomized pilot non-inferiority trial

Reproductive BioMedicine Online ·doi:10.1016/j.rbmo.2025.105125

RESEARCH QUESTION: Is oral administration of a gonadotrophin releasing hormone (GnRH) antagonist for 2 months before euploid embryo transfer in patients with endometriosis non-inferior to intramuscular administration of a long-acting GnRH a…

2024

ABERRANT MAPK3/1 AND AKT SIGNALING PATHWAYS IN GRANULOSA CELLS MAY CONTRIBUTE TO THE COMPROMISED FOLLICULAR DEVELOPMENT OF THE ENDOMETRIOSIS PATIENTS

·doi:10.1016/j.fertnstert.2024.07.295

other 2024

Correlation of maternal factors in egg freezing cycles with in vitro fertilization outcomes of both in vivo and rescue in vitro matured oocytes

F&S reports ·doi:10.1016/j.xfre.2024.06.005

2024

PROLONGED ORAL GnRH ANTAGONIST ADMINISTRATION PRIOR TO EUPLOID EMBRYO TRANSFER (ET) IN ENDOMETRIOSIS (ENDO) PATIENTS: A PROSPECTIVE RANDOMIZED NON-INFERIORITY TRIAL

·doi:10.1016/j.fertnstert.2024.07.381

2023

HYPOXIA CONDITION AND MITOQUINONE TREATMENT RESTORE CELL PROLIFERATION AND MITOCHONDRIAL MEMBRANE POTENTIAL OF GRANULOSA CELLS DERIVED FROM ENDOMETRIOSIS PATIENT DURING IN VITRO CULTURE

·doi:10.1016/j.fertnstert.2023.08.406

lab-animal 2021

Increased Systemic Antioxidant Power Ameliorates the Aging-Related Reduction in Oocyte Competence in Mice

International journal of molecular sciences ·doi:10.3390/ijms222313019

Ovarian aging is associated with elevated oxidative stress and diminished oocyte developmental competence. We aimed to determine the impact of systemic antioxidant treatment in aged mice. Female outbred CF-1 mice were aged for 9 months prio…

other 2018

The impact of infertility diagnosis on embryo-endometrial dialogue

Reproduction (Cambridge, England) ·doi:10.1530/rep-17-0566

Initial stages of implantation involve bi-directional molecular crosstalk between the blastocyst and endometrium. This study investigated an association between infertility etiologies, specifically advanced maternal age (AMA) and endometrio…

observational 2017

GnRH agonist administration prior to embryo transfer in freeze-all cycles of patients with endometriosis or aberrant endometrial integrin expression

Reproductive BioMedicine Online ·doi:10.1016/j.rbmo.2017.05.004

Prolonged gonadotrophin-releasing hormone agonist (GnRHa) administration before IVF with fresh embryo transfer to patients with endometriosis or aberrant endometrial integrin expression (-integrin) improves outcomes but may suppress ovarian…

2016

Embryo-endometrial dialogue is altered in endometriosis patients through microRNA regulation

·doi:10.1016/j.fertnstert.2016.07.275

2016

Prolonged administration of GnRH agonist (GnRHa) prior to embryo transfer (ET) in endometriosis (ENDO) and integrin (INT)negative patients: the impact of freeze-all cycles

·doi:10.1016/j.fertnstert.2016.07.775

review 2009

Adjuncts for ovarian stimulation: when do we adopt "orphan indications" for approved drugs?

Fertility and sterility ·doi:10.1016/j.fertnstert.2009.03.081

Several drugs, shown to be safe for other uses, have proven to be highly effective adjuncts for ovarian stimulation. The authors evaluate these "orphan" indications and make recommendations so that more patients will benefit from their use.

rct 2009

Does endometrial integrin expression in endometriosis patients predict enhanced in vitro fertilization cycle outcomes after prolonged GnRH agonist therapy?

Fertility and sterility ·doi:10.1016/j.fertnstert.2008.12.023

OBJECTIVE: To determine whether endometrial expression of the integrin alpha(v)beta(3) vitronectin can predict which endometriosis patient subgroup will benefit from pre-IVF cycle prolonged GnRH agonist (GnRHa) therapy. DESIGN: Prospective…

2007

Does endometrial αvβ3 vitronectin (β3) expression in endometriosis (ENDO) patients predict enhanced outcomes after prolonged GnRH agonist (GnRHa) therapy prior to in vitro fertilization (IVF)?

·doi:10.1016/j.fertnstert.2007.07.440

other 2007

The incidence of aberrant endometrial alphavbeta(3) vitronectin expression in a high risk infertility population: could prolonged GnRH agonist therapy play a role?

Journal of assisted reproduction and genetics ·doi:10.1007/s10815-007-9164-3

PURPOSE: Evaluate the incidence of aberrant endometrial integrin (alphavbeta(3) vitronectin) expression in patients at high risk for implantation defects. MATERIALS AND METHODS: Retrospective case-control trial of 74 consecutive infertile …

review 2003

Does surgical management of endometriosis within 6 months of an in vitro fertilization-embryo transfer cycle improve outcome?

Journal of assisted reproduction and genetics ·doi:10.1023/a:1025429027610

PURPOSE: To assess the effect on cycle outcome of surgery for endometriosis performed in the 6 months prior to in vitro fertilization-embryo transfer (IVF-ET). METHODS: Retrospective analysis of all patients with a primary diagnosis of end…

review 2003

Management of endometriosis-associated infertility

Obstetrics and Gynecology Clinics of North America ·doi:10.1016/s0889-8545(02)00061-x

Management of infertility associated with endometriosis remains challenging. The clinician must rule out all other causes of infertility before creating a treatment plan. It is important to remember that women with infertility and endometri…

2003

Tratamiento de la infecundidad relacionada con endometriosis

observational 2002

Assisted Reproduction Does Surgical Management of Endometriosis Within 6 Months of an In Vitro Fertilization–Embryo Transfer Cycle Improve Outcome?1

Purpose: To assess the effect on cycle outcome of surgery for endometriosis performed in the 6 months prior to in vitro fertilization–embryo transfer (IVF-ET). Methods: Retrospective analysis of all patients with a primary diagnosis of endo…

rct 2002

Effect of prolonged gonadotropin-releasing hormone agonist therapy on the outcome of in vitro fertilization-embryo transfer in patients with endometriosis

Fertility and sterility ·doi:10.1016/s0015-0282(02)03373-3

OBJECTIVE: To evaluate the effect of a 3-month course of GnRH agonist administered immediately before IVF-ET in infertile patients with endometriosis. DESIGN: Prospective, randomized trial. SETTING: Three tertiary care assisted reproducti…

2001

Does surgical management of endometriosis (ENDO) within 6 months of in vitro fertilization-embryo transfer (IVF-ET) improve cycle outcome?

·doi:10.1016/s0015-0282(01)02312-3

2001

The effect of prolonged GnRH agonist (GnRHa) therapy on in vitro fertilization-embryo transfer (IVF-ET) cycle outcome in endometriosis (ENDO) patients: a multicenter randomized trial.

·doi:10.1016/s0015-0282(01)02442-6