Mitochondrial dysfunction has been implicated in the pathophysiology of endometriosis, but the role of ubiquitin-specific protease 2 (USP2) remains unclear. This study aimed to determine whether USP2 modulates mitochondrial respiratory acti…
OBJECTIVE: Proteomic analysis was conducted on human follicular fluid (FF) using the 4D label-free method to identify proteins potentially influencing oocyte quality in hyperandrogenic (HA) polycystic ovary syndrome (PCOS) patients. METHOD…
BACKGROUND: Low-grade chronic inflammation is observed in women with polycystic ovary syndrome (PCOS). A recent genome-wide association study (GWAS) suggested that several inflammation marker levels were altered in the blood routine tests i…
Endometriosis involves ectopic growth of endometrial-like tissue, yet the spatial transcriptomic and metabolic landscape of ovarian endometriomas remains poorly understood. This investigation presents a comprehensive multi-omics analysis of…
Mesenchymal cells constitute the primary structural support elements within endometriotic lesions, yet their pivotal roles in endometriotic pathogenesis remain largely uncharted. This study aimed to construct a single-cell atlas of endometr…
PURPOSE: The aim was to investigate the value of the application of a progesterone-primed ovarian stimulation (PPOS) protocol in patients with ovarian endometriosis (OEM) combined with diminished ovarian reserve (DOR). MATERIALS AND METHOD…
PURPOSE: This paper was mainly conducted to investigate the effect of chronic endometritis (CE) on the clinical outcome of patients with unexplained infertility. MATERIALS AND METHODS: 145 patients with unexplained infertility from the Rep…
Endometriosis (EM) is a chronic inflammatory disease affecting women aged between 23 and 42 years with a prevalence of 6%-10%. S100A7, a member of the S100 protein family, has been implicated in promoting inflammation. However, the role of …
Objective To investigate the expression levels of YKL-40 and CA125 in the serum and peritoneal fluid of patients with endometriosis (EMS), and discuss the relationship between YKL-40, and CA125. Methods From March 2012 to March 2014,…
The technology of in vitro fertilization and embryo transfer(IVF-ET) make a great progress in recent years, however, the clinical pregnancy rate in IVF-ET cycles has remained at about 40%.So how to improve the clinical pregnancy rate in IVF…