Kiriaki Papaikonomou

ORCID: 0000-0002-0862-6265 · 4 papers in corpus
other 2026
Individualised progesterone receptor modulator prevention strategies for triple-negative breast cancer in BRCA1 pathogenic variant carriers.
NPJ breast cancer ·doi:10.1038/s41523-026-00998-x

Women with germline BRCA1 pathogenic variants face a very high risk of early-onset triple-negative breast cancer (TNBC), with risk-reducing mastectomy currently the only established preventive option. Emerging evidence suggests aberrant pro…

2026
Single-cell study of human ovarian response to phthalate exposure reveals glial cell susceptibility and disruption of adhesion and mitochondrial pathways.
EBioMedicine ·doi:10.1016/j.ebiom.2026.106487

BackgroundPhthalates are known male endocrine disruptors and reproductive toxicants. Despite growing evidence of female effects, mechanistic knowledge in key reproductive organs remains limited, hindering regulations. Here, we conducted an …

rct 2022
Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
Genome medicine ·doi:10.1186/s13073-022-01063-5

BACKGROUND: Breast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to the development of poor-prognostic breast cancers. However, it is not known if antagonising …

rct 2020
Effects of the levonorgestrel intrauterine system on the endometrium after long-term exposure to mifepristone: Secondary outcomes of a randomized controlled trial
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2020.06.056

OBJECTIVE: Long-term treatment with progesterone receptor modulators (PRM) is associated with a distinct histological entity termed progesterone receptor modulator associated endometrial changes (PAEC). While accumulating evidence implies t…