Xiaolei Liang

ORCID: 0000-0001-6032-3061 · 2 papers in corpus

lab-animal 2026

Lipidomic Remodeling by HILPDA in Granulosa Cells Impairs Ovarian Reserve Through Disruption of Mitochondrial and Endoplasmic Reticulum Homeostasis

FASEB journal : official publication of the Federation of American Societies for Experimental Biology ·doi:10.1096/fj.202600847rrrr

Diminished ovarian reserve (DOR) is characterized by a decline in oocyte quantity and/or quality and represents a growing cause of female infertility, particularly among young women, yet its pathogenesis remains incompletely understood. Dis…

other 2022

Decreased fatty acids induced granulosa cell apoptosis in patients with diminished ovarian reserve

Journal of assisted reproduction and genetics ·doi:10.1007/s10815-022-02462-8

PURPOSE: To investigate whether fatty acid changes in granulosa cells (GCs) underly the pathogenic mechanisms of diminished ovarian reserve (DOR). METHODS: GCs were obtained from patients with DOR (n = 70) and normal ovarian reserve (NOR, …