Elisa Varela

ORCID: 0000-0002-5361-3877 · 3 papers in corpus
other 2026
Mathematical modelling of premature haematopoietic ageing in dyskeratosis congenita
Scientific reports ·doi:10.1038/s41598-026-48498-z

Idiopathic dyskeratosis congenita (DC) is a disorder characterized by mucocutaneous alterations, bone-marrow failure, immune deficiency, liver cirrhosis, and other morbidities, due to alterations in telomere maintenance, which, in most case…

rct 2023
A Randomized Controlled Intervention Trial with Danazol to Improve Telomeric and Fertility Parameters in Women with Diminished Ovarian Reserve: A Pilot Study
Women's health reports (New Rochelle, N.Y.) ·doi:10.1089/whr.2023.0013

BACKGROUND: Most women who are treated at in vitro fertilization (IVF) clinics have trouble conceiving due to ovarian failure (OF), which seems to be associated to short telomeres and reduced or absent telomerase activity in their granulosa…

rct 2022
P-629 A prospective, randomized, placebo-controlled pilot trial investigating telomere length dynamics and ovarian function in patients with diminished ovarian reserve (DOR) after danazol treatment
·doi:10.1093/humrep/deac107.578

Abstract Study question Could the administration of a synthetic steroid -danazol- for 3 months reactivate telomerase activity and lengthen telomeres in patients with DOR? Summary answer Danazol treatment resulted in an increase of the mean …