Mary Wingfield

Objective To investigate the approach of obstetricians and gynaecologists in Ireland to optimising the fertility of young women with moderate to severe endometriosis, who have not yet completed their family. Design Scoping questionnaire Set…

Endometriosis is a chronic systemic disease, which results in endometrial-type tissue growing outside the uterus, and affects approximately 10% of reproductive-aged women worldwide. Its aetiology is poorly understood, and there is currently…

Endometriosis is a chronic disease, affecting approximately 10% of women of reproductive age. Ovarian endometriotic cysts or endometriomas are of particular relevance to fertility due to the negative impacts of both the disease and its trea…

Endometriosis is a chronic inflammatory gynaecological disease characterized by the growth of endometrial tissue outside the uterine cavity. There are currently no definitive non-invasive diagnostic tools. Glycosylation is the most common p…

Abstract Study question Can a network-based integrative analysis (NBIA) meta-analysis approach be used to identify clinically relevant cumulus-oocyte complex biological pathway and gene targets in women with endometriosis? Summary answer Bi…

The management of endometriomas in women wishing to preserve their fertility is complex. While surgery can help to achieve pregnancy in some, it may also have a detrimental effect on a woman's ovarian reserve. The present article reviews th…

Abstract Study question Is the expression of IL–17A and antimicrobial peptides (AMPs) altered in endometriosis? Summary answer IL–17A protein levels were similar in the endometrium of women with and without endometriosis but the expression …

Abstract Study question Could glycosylation changes on serum and/or urine glycoproteins be suitable biomarkers for the non-invasive diagnosis of endometriosis? Summary answer The glycosylation pattern on serum and urine glycoproteins differ…

Abstract Study question Do women undergoing surgery for endometrioma due to pain, a cyst and/or subfertility understand the impact of the disease and its treatment on ovarian reserve and fertility. Summary answer The majority of women treat…

The aim of these case reports and literature review is to report the importance of cyclical variation of serum CA-125 levels in two patients with endometriosis. Two case reports and a literature review of cyclical variation in serum CA-125 …

PROBLEM: Uterine natural killer (uNK) cells play a critical role early in gestation. As we previously identified altered uNK cell development in endometriosis-associated infertility, we herein sought to characterize natural killer (NK) cell…

OBJECTIVE: To identify women, on the basis of clinical history and serum anti-Müllerian hormone (AMH) levels, who are at risk of premature ovarian insufficiency and thereby guide appropriate early referral for egg freezing. METHODS: In a re…

PROBLEM: Uterine natural killer (uNK) cells play a significant role in successful human pregnancy. Having previously demonstrated uNK cell progenitors in human endometrium, we hypothesized that abnormal uNK cell maturation contributes to in…

Endometriosis affects more than 10% of women, causing significant pain and morbidity. It is also a significant cause of infertility. The aetiology of the disease remains an enigma, and the mechanisms responsible for the associated infertili…

Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)

SummaryA structured questionnaire was employed to compare symptomatology between patients with newly diagnosed endometriosis and a control group. A number of symptoms, including constipation, diarrhoea, nocturnal micturition, bloating and l…

Twenty-three women with laparoscopically diagnosed early-stage endometriosis collected daily saliva samples at home and brought them to the laboratory at the completion of each menstrual cycle. Levels of progesterone in the saliva were dete…