Wai-Yee Chan

No ORCID on file · 4 papers in corpus
lab-animal 2021
lncRNA GCAT1 is involved in premature ovarian insufficiency by regulating p27 translation in GCs via competitive binding to PTBP1
Molecular therapy. Nucleic acids ·doi:10.1016/j.omtn.2020.10.041

Dysfunction of granulosa cells (GCs) leading to follicle atresia has been extensively studied as a major cause of premature ovarian insufficiency (POI), but the regulatory role of long non-coding RNAs (lncRNAs) in this process is still poor…

observational 2020
Fertility factors affect the vaginal microbiome in women of reproductive age
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.13220

PROBLEM: For women of reproductive age, achieving a successful pregnancy requires both the normal functioning of reproductive endocrine and the health of the reproductive tract environment. We aimed to study how these fertility factors, suc…

other 2020
Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1
Nucleic acids research ·doi:10.1093/nar/gkaa127

The genetic etiology of premature ovarian insufficiency (POI) has been well established to date, however, the role of long noncoding RNAs (lncRNAs) in POI is largely unknown. In this study, we identified a down-expressed lncRNA HCP5 in gran…

review 2012
Flexible and versatile as a chameleon-sophisticated functions of microRNA-199a
International journal of molecular sciences ·doi:10.3390/ijms13078449

Although widely studied in the past decade, our knowledge of the functional role of microRNAs (miRNAs) remains limited. Among the many miRNAs identified in humans, we focus on miR-199a due to its varied and important functions in diverse mo…