BACKGROUND: Sex hormones have been implicated in leukemogenesis, but evidence regarding hormonal contraceptive use and leukemia risk remains limited and primarily based on older formulations. Given the widespread use of contemporary hormona…
PURPOSE: While having a chronic medical disease (CMD) increases use of analgesics and anti-inflammatory drugs, sufficient knowledge regarding patterns of use during pregnancy is lacking. We aimed to describe ibuprofen use before and in earl…
PURPOSE: To investigate the association between hormonal contraceptive use and the risk of retinal vascular occlusions in women of reproductive age. DESIGN: Register-based, nationwide cohort study. PARTICIPANTS: A total of 2,208,172 women…
OBJECTIVE: To evaluate the association between contemporary hormonal contraceptive use and the risk of incident ischaemic stroke and myocardial infarction. DESIGN: Real-world, nationwide, prospective cohort study. SETTING: Denmark, by use…
OBJECTIVE: To estimate the rate of breast cancer associated with use of vaginal oestradiol tablets according to duration and intensity of their use. DESIGN: Registry based, case-control study, nested in a nationwide cohort. SETTING: Based…
BACKGROUND: Use of the high-dose levonorgestrel-releasing intrauterine system (LNG-IUS) has been associated with increased risk of incident depression. Evidence is lacking on the influence of use of two recently marketed low-dose LNG-IUS on…
OBJECTIVE: To study the influence of concomitant use of hormonal contraception and non-steroidal anti-inflammatory drugs (NSAIDs) on the risk of venous thromboembolism. DESIGN: Nationwide cohort study. SETTING: Denmark through national re…
BACKGROUND: Oral tranexamic acid is effective for heavy menstrual bleeding, but the thrombosis risk with this treatment is largely not studied. METHODS: Using nationwide registries, we assessed associations between use of oral tranexamic a…
OBJECTIVES: To investigate the association between contemporary combined hormonal contraceptives (including progestogen types in combined preparations and all progestogen-only products) and overall and specific types of ovarian cancer. DES…
IMPORTANCE: The association between the use of hormonal contraceptive and pancreatic cancer among premenopausal women has until now been unclear. This is the first study to investigate the risk of pancreatic cancer in pre-menopausal women. …