Huirong Xie

No ORCID on file · 2 papers in corpus

lab-animal 2010

Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress

Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1009324107

Immunophilin FK506-binding protein 52 (FKBP52) is a cochaperone that binds to the progesterone receptor (PR) to optimize progesterone (P(4))-PR signaling. We recently showed that Fkbp52-deficient (Fkbp52(-/-)) mice have reduced uterine PR r…

lab-animal 2007

FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific

The Journal of clinical investigation ·doi:10.1172/JCI31622

Immunophilin FKBP52 serves as a cochaperone to govern normal progesterone (P(4)) receptor (PR) function. Using Fkbp52(-/-) mice, we show intriguing aspects of uterine P(4)/PR signaling during pregnancy. Implantation failure is the major phe…