Gillian Rose

OBJECTIVE: To correlate the clinical history with imaging findings of women with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. DESIGN: Retrospective cohort study. SETTING: A UK IOTA and ESGO-certified tertiary referral centre for disord…

Objective: to correlate the clinical history with imaging findings of women with MRKH Design: Retrospective cohort study Setting: A UK IOTA and ESGO-certified tertiary referral centre for disorders of reproductive development Population: Al…

Mayer-Rokitansky-Küster–Hauser (MRKH) syndrome is a congenital disorder characterised by uterine and vaginal hypoplasia. Magnetic resonance imaging (MRI) is the gold standard for diagnosis. Imaging features of MRKH have been correlated with…

Abstract Background Deeply infiltrating endometriosis has an estimated prevalence of 1% in women of reproductive age. Ninety percent have rectovaginal lesions but disease may also include the bowel, bladder and ureters. Current practice oft…

SummaryFollowing laparoscopic diagnosis and staging (American Fertility Society) of endometriosis, 269 patients, recruited from 10 hospitals, were allocated at random to groups receiving either gestrinone (2—5 mg) twice weekly (n = 132) or …

In a large, double-blind, multicentre study, 269 patients with confirmed endometriosis were randomly allocated to receive either danazol (200 mg twice daily; n = 137) or gestrinone (2.5 mg twice weekly; n = 132) for 6 months. The two groups…

SummaryThe endocrine effects of danazol and goserelin were studied in 10 and 20 women with endometriosis, respectively. Goserelin caused a profound degree of hypogona-dotrophic hypo-oestrogenism comparable with complete ovarian ablation. Da…

SUMMARY In an attempt to determine whether the suppression in oestradiol levels caused by danazol is due to an effect on the hypothalamic‐pituitary axis, we compared the endocrine effects of danazol with those of the LHRH (GnRH) agonist ana…

This thesis describes an investigation of the clinical efficacy and mechanisms of action of danazol and the newer steroidal agent, gestrinone in the medical management of endometriosis. A prospective randomized double-blind study was perfor…

Danazol and gestrinone are both effective agents in the treatment of endometriosis. Their mechanism of action is unknown but may be related to their androgenic activity, which is at least partly dependent on increases in the proportion of t…

Danazol is known to cause marked suppression of sex hormone binding globulin (SHBG) levels in plasma and to increase the proportion of plasma testosterone unbound to protein but the effect on the concentration of total and free testosterone…