Shijie Chen

No ORCID on file · 1 paper in corpus

lab-animal 2025

Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration

Journal of neuroinflammation ·doi:10.1186/s12974-025-03335-4

BACKGROUND: Intervertebral disc degeneration (IDD) is a leading cause of low back pain, often linked to inflammation and pyroptosis in nucleus pulposus (NP) cells. The role of Periostin (POSTN) in IDD remains unclear. OBJECTIVE: This study…