Alfredo Ulloa-Aguirre

review 2023

Follicle-Stimulating Hormone Biological Products: Does Potency Predict Clinical Efficacy?

International journal of molecular sciences ·doi:10.3390/ijms24109020

Follicle-stimulating hormone (FSH), together with luteinizing hormone (LH) and human chorionic gonadotropin (hCG), plays a fundamental role in human reproduction. The discovery of FSH and other gonadotropins was a defining moment in our und…

lab-animal 2022

Comparative Assessment of the Structural Features of Originator Recombinant Human Follitropin Alfa Versus Recombinant Human Follitropin Alfa Biosimilar Preparations Approved in Non-European Regions.

International journal of molecular sciences ·doi:10.3390/ijms23126762

Although the full primary structures of the alfa and beta subunits of reference r-hFSH-alfa and its biosimilars are identical, cell context-dependent differences in the expressing cell lines and manufacturing process can lead to variations …

observational 2018

Frequency of the T307A, N680S, and -29G>A single-nucleotide polymorphisms in the follicle-stimulating hormone receptor in Mexican subjects of Hispanic ancestry

Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-018-0420-4

BACKGROUND: FSHR SNPs may influence the ovarian sensitivity to endogenous and exogenous FSH stimulation. Given the paucity of data on the FSHR c.919A > G, c.2039A > G and - 29G > A SNPs in Hispanic population, we here analyzed their frequen…

lab-animal 2009

Conformational effects of Lys191 in the human GnRH receptor: mutagenesis and molecular dynamics simulations studies

The Journal of endocrinology ·doi:10.1677/joe-08-0527

In the present study, we analyzed the role of Lys191 on function, structure, and dynamic behavior of the human GnRH receptor (hGnRHR) and the formation of the Cys14-Cys200 bridge, which is essential for receptor trafficking to the plasma me…