David T. Curiel

ORCID: 0000-0003-3802-6014 · 3 papers in corpus
lab-animal 2010
A conditionally replicative adenovirus, CRAd-S-pK7, can target endometriosis with a cell-killing effect
Human Reproduction ·doi:10.1093/humrep/deq137

BACKGROUND: Novel therapeutic approaches for endometriosis based on molecular strategies may prove to be useful. Conditionally replicative adenoviruses (CRAds) are designed to exploit key differences between target and normal cells. The wil…

lab-animal 2010
Treatment of endometriosis with a VEGF-targeted conditionally replicative adenovirus
Fertility and sterility ·doi:10.1016/j.fertnstert.2009.04.042

OBJECTIVE: To evaluate a vascular endothelial growth factor (VEGF)-targeted gene therapy for the treatment of endometriosis. DESIGN: Analysis of the VEGF gene expression and promoter activity in ectopic and eutopic endometrium. Evaluation …

lab-animal 2008
Toward gene therapy of endometriosis: transductional and transcriptional targeting of adenoviral vectors to endometriosis cells
American journal of obstetrics and gynecology ·doi:10.1016/j.ajog.2008.01.059

OBJECTIVE: The purpose of this study was to screen a panel of targeted adenoviruses as vectors for endometriosis gene therapy. STUDY DESIGN: Endometriotic cells were obtained from subjects with ovarian endometriomas. Liver tissues were tak…