Risch A

ORCID: 0000-0002-8026-5505 · 3 papers in corpus
other 2022
Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells
Epigenetics ·doi:10.1080/15592294.2021.1959976

Cystic fibrosis (CF) is a monogenic disease, characterized by massive chronic lung inflammation. The observed variability in clinical phenotypes in monozygotic CF twins is likely associated with the extent of inflammation. This study sought…

review 2017
The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology ·doi:10.1158/1055-9965.epi-16-0106

BACKGROUND: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping …

meta-analysis 2012
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls
Human molecular genetics ·doi:10.1093/hmg/dds334

Recent genome-wide association studies (GWASs) have identified common genetic variants at 5p15.33, 6p21-6p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) an…