Xiangjie Guo — Endo Lab

lab-animal 2023

Jinfeng pills ameliorate premature ovarian insufficiency induced by cyclophosphamide in rats and correlate to modulating IL-17A/IL-6 axis and MEK/ERK signals

Journal of ethnopharmacology ·doi:10.1016/j.jep.2023.116242

ETHNOPHARMACOLOGICAL RELEVANCE: Jinfeng Pill (JFP) is a classical Chinese medicine formula and composed of 9 herbs, including Epimedium brevicornu Maxim (Yinyanghuo), Cervus elaphus Linnaeus (Lurong), Panax ginseng C.A.Mey. (Renshen), Equus…

lab-animal 2023

Nomegestrol acetate ameliorated adipose atrophy in a rat model of cisplatin‑induced cachexia

Experimental and therapeutic medicine ·doi:10.3892/etm.2022.11723

Cachexia, a complex disorder that results in depletion of adipose tissue and skeletal muscle, is driven by anorexia, metabolic abnormalities and inflammation. There are limited therapeutic options for this syndrome. Previous evidence has de…

2015

Ginsenoside Rh2 suppresses growth of uterine leiomyoma in vitro and in vivo and may regulate ERα/c-Src/p38 MAPK activity

·doi:10.1016/j.jff.2015.06.057

lab-animal 2014

Evaluation of biodegradable microspheres containing nomegestrol acetate in a rat model of endometriosis

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences ·doi:10.1016/j.ejps.2014.08.011

We assessed the efficacy of biodegradable microspheres (MSs) containing nomegestrol acetate (NOMAC) for treatment of endometriosis in a rat model and investigated its preliminary mechanism of action. Sprague-Dawley rats with surgically impl…