STUDY OBJECTIVE: To evaluate differences in the likelihood of endometriosis or adenomyosis diagnosis across genetically-defined ancestry groups (African, Admixed American, East Asian, European, and South Asian), and to determine whether soc…
We report the findings of a genome-wide association study (GWAS) meta-analysis of endometriosis across 14 biobanks worldwide, including 32% non-European patient participants, as part of the Global Biobank Meta-Analysis Initiative (GBMI). Ou…
Endometriosis is a complex and heterogeneous condition affecting 10% of reproductive-age women, and yet, it often goes undiagnosed for several years. Limited observed heritability (7%) of large genetic association studies may be attributabl…
BACKGROUND: Endometriosis affects 10% of reproductive-age women, and yet, it goes undiagnosed for 3.6 years on average after symptoms onset. Despite large GWAS meta-analyses (N > 750,000), only a few dozen causal loci have been identified. …
Endometriosis is a chronic, complex disease for which there are vast disparities in diagnosis and treatment between sociodemographic groups. Clinical presentation of endometriosis can vary from asymptomatic disease-often identified during (…
BACKGROUND: Given no consensus in the literature, this study sought to determine if a protocol of measuring serum estradiol and progesterone the day prior to frozen embryo transfer (FET) improves likelihood of pregnancy and livebirth. METH…
Preterm birth (PTB) affects approximately 1 in 10 pregnancies and contributes to approximately 50% of neonatal mortality. However, despite decades of research, little is understood about the etiology of PTB, likely due to the multifactorial…
OBJECTIVE: To determine whether live birth rates differ by type of endometrial preparation in frozen embryo transfer (FET) cycles. DESIGN: Retrospective cohort study. SETTING: Academic fertility center. PATIENT(S): Reproductive-aged wome…
Hintergrund: Bei etwa 10% aller Frauen liegt eine Endometriose vor, die Ursache nicht nur chronischer Schmerzen, sondern auch einer Infertilität sein kann. In diesem Zusammenhang interessieren die Ergebnisse der In-vitro-Fertilisation (IVF)…
OBJECTIVE: To assess the impact of endometriosis, alone or in combination with other infertility diagnoses, on IVF outcomes. DESIGN: Population-based retrospective cohort study of cycles from the Society for Assisted Reproductive Technolog…
Endometriosis is associated with infertility; however, the etiology of this association is unclear, thus complicating management. Several mechanisms of pathogenesis have been proposed; however, no one theory has been implicated. Medical the…