Francine Laden

Although the menstrual cycle is a vital sign for women's health, research investigating menstrual cycle length (MCL) trajectories across reproductive life is scarce, often categorizing just two patterns: regular and irregular. We used laten…

BACKGROUND: Solar ultraviolet radiation (UV) is a critical environmental factor for dermal conversion of vitamin D, which is suggested to support reproductive health. However, current epidemiological studies have reported conflicting result…

UNLABELLED: Previous studies have suggested noise, especially at night time, and light at night (LAN) could cause neuroendocrine disturbance and circadian disruption, which may lead to ovarian follicle atresia and earlier onset of menopause…

OBJECTIVE: To examine the association between ambient temperature and antral follicle count (AFC), a standard measure of ovarian reserve. DESIGN: Prospective cohort study. SETTING: Fertility center at an academic hospital in the northeast…

Evidence has shown associations between air pollution and traffic-related exposure with accelerated aging, but no study to date has linked the exposure with age at natural menopause, an important indicator of reproductive aging. In this stu…

BACKGROUND: Natural vegetation, or greenness, is thought to improve health through its ability to buffer and reduce harmful environmental exposures as well as relieve stress, promote physical activity, restore attention, and increase social…

Accumulating evidence suggests that air pollution increases pregnancy loss; however, most previous studies have focused on case identification from medical records, which may underrepresent early pregnancy losses. Our objective was to inves…

BACKGROUND: An increasing number of studies have linked air pollution to decreased fertility. Whether this is due to an effect on ovarian reserve is unknown. METHOD: Our study included 632 women attending the Massachusetts General Hospital…

Traffic-related air pollution has been linked to higher risks of infertility and miscarriage. We evaluated whether folate intake modified the relationship between air pollution and livebirth among women using assisted reproductive technolog…

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BACKGROUND: Particulate matter and proximity to large roadways may promote disease mechanisms, including systemic inflammation, hormonal alteration, and vascular proliferation, that may contribute to the development and severity of endometr…