Heinrich Husslein

No ORCID on file · 12 papers in corpus · active 2015-2024

Study types

  • article 8
  • other 3
  • review 1

Condition tags

  • mesh:D004715 12
  • endometriosis 12
  • infertility 3
article 2024
BMC medicine ·doi:10.1186/s12916-024-03733-0

BACKGROUND: Endometriosis is a chronic, estrogen-dependent, benign condition, affecting 10-15% of women of reproductive age. It is associated with a prevalence of sexual dysfunction that is nearly twice as high as that seen in women with ot…

other 2023
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2023.06.006

RESEARCH QUESTION: What is the role of DIRAS3 in endometriosis pathogenesis? DESIGN: Prospective patient cohort study combined with experiments in the 12Z human endometriosis epithelial cell line model to determine the role of DIRAS3 in en…

review 2022
Expert opinion on pharmacotherapy ·doi:10.1080/14656566.2022.2045274

INTRODUCTION: Endometriosis is a benign disease, characterized by a wide range of symptoms and different degrees of severity, which is why therapy should be individually adapted to the patient's needs. Over the years, a lot of research has …

article 2020
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-020-00211-9

Abstract Endometriosis is a chronic inflammatory disease associated with an impaired immune response at the site of lesion implantation. The ability of macrophages to respond to changes in their environment is critical for an effective immu…

article 2020
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2020.01.014
other 2019
Molecular human reproduction ·doi:10.1093/molehr/gay042

STUDY QUESTION: Are increased sVCAM-1 and sICAM-1 levels associated with tumor necrosis factor-alpha-converting enzyme (TACE) activity in endometriosis? SUMMARY ANSWER: Here we provide the first functional evidence that induced TACE activi…

article 2018
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2018.05.007
article 2017
Experimental biology and medicine (Maywood, N.J.) ·doi:10.1177/1535370217742600

The objective of our pilot clinical, prospective study was to determine the serum levels of mature brain-derived neurotrophic factor, in of women with endometriosis and controls and explore whether mature brain-derived neurotrophic factor i…

article 2016
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2016.07.500
article 2016
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-016-0215-4

BACKGROUND: Current evidence suggests that endometrial-derived stem cells, spilled in the peritoneal cavity via retrograde menstruation, are key players in the establishment of endometriotic lesions. The aim of this study was to determine t…

article 2015
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-015-0063-7

BACKGROUND: Epithelial to mesenchymal transition (EMT) is a process in which epithelial cells lose polarity and cell-to-cell contacts and acquire the migratory and invasive abilities of mesenchymal cells. These abilities are thought to be p…

other 2015
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2015.10.016

OBJECTIVE: Gonadotropin releasing hormone agonists (GnRHa) decrease the expression of growth factors involved in the development of human endometriotic tissue. As endometriosis has been found to be associated with a mild increase in prolact…