Tomoko Nakamura

Python code used for the analyses reported in the manuscript. Covers the paired analysis of eight patients, the calculation of R² for PERMANOVA, contamination screening, repeated rarefaction for the diversity analyses, summarization of the …

Python code used for the analyses reported in the manuscript. Covers the paired analysis of eight patients, the calculation of R² for PERMANOVA, contamination screening, repeated rarefaction for the diversity analyses, summarization of the …

Python code used for the analyses reported in the manuscript. Covers the paired analysis of eight patients, the calculation of R² for PERMANOVA, contamination screening, repeated rarefaction for the diversity analyses, summarization of the …

Python code used for the analyses reported in the manuscript. Covers the paired analysis of eight patients, the calculation of R² for PERMANOVA, contamination screening, repeated rarefaction for the diversity analyses, summarization of the …

PURPOSE: Decidualization of endometrial stromal cells involves significant morphological and functional changes in which alpha-smooth muscle actin (αSMA) expression decreases. Meflin, a glycosylphosphatidylinositol-anchored protein, suppres…

PURPOSE: This study aimed to develop international expert consensus statements on chronic endometritis (CE) through a comprehensive literature review of existing evidence and a modified Delphi approach. METHODS: Ten panelists of the Japan …

The involvement of microbiota in the pathogenesis of endometriosis has been increasingly suggested; however, existing evidence remains inconsistent, largely owing to the challenges of analyzing extremely low-biomass samples. To clarify whet…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common cause of irregular menstrual cycles and infertility. Current treatments primarily involve ovulation induction and sex steroid hormone therapy. Tokishakuyakusan (TSS) is a traditional …

BACKGROUND: Endometriosis is an estrogen-dependent chronic inflammatory disease, however the mechanisms underlying inflammation remain unclear. Non-hormonal drugs that can prevent endometriosis progression and resolve endometriotic infertil…

Abstract Extracellular vesicles (EVs) are secreted from mammalian cells and bacteria and are involved in disease pathogenesis. Recently, bacterial factors have been linked to the pathogenesis of endometriosis. Therefore, identifying host-ba…

AIM: Diffuse uterine leiomyomatosis (DUL) is characterized by numerous uterine leiomyomas within and diffusely replacing the myometrium. However, because of its rarity, the prevalence, diagnostic criteria, and standard treatment for patient…

Aging drives excessive ovarian oxidative stress (OS), impairing fertility and affecting granulosa cells (GCs), which are involved in folliculogenesis. This study aims to clarify the relationship between OS and autophagy in GCs and to identi…

BRCA1 is one of the causative genes for hereditary breast and ovarian cancer syndrome with a high risk of early-onset breast cancer. Whereas olaparib (OLA), an inhibitor of poly-ADP-ribose polymerase, has been applied as adjuvant therapy to…

INTRODUCTION: Endometriosis can cause of infertility, and evaluation methods for predicting clinical pregnancy outcomes are desired. Extracellular vesicles (EVs) exist in blood and it contains small non-coding RNAs (ncRNAs) that may reflect…

BACKGROUND: Assisted reproductive technology accounts for an increasing proportion of infertility treatments, and assessments to predict clinical pregnancy outcomes are desired. Extracellular vesicles exist in follicular fluid, and small no…

Ovarian endometrioma (OE) is a common gynecological disease that is often treated with surgery and hormonal treatment. However, ovarian cystectomy can impair the ovarian reserve (OR). Previously, we showed that perioperative administration …

BACKGROUND: Endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects 10% of women of reproductive age. Ovarian endometriosis (OE) is the most common lesion in endometriosis and may…

Early diagnosis and long-term management of endometriosis is important in adolescent girls considering their potential for future pregnancy and need for preventing disease progression. However, symptoms and clinical findings of adolescent e…

Abstract Background Endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects 10% of women of reproductive age. Ovarian endometriosis (OE) is the most common lesion in endometriosis…

BACKGROUND: Ovarian endometrioma is a common gynecological disease that is often treated with surgery or hormonal treatment. Ovarian cystectomy, a surgical procedure for ovarian endometrioma, can result in impaired ovarian reserve. METHODS…

Appendiceal intussusception secondary to endometriosis is extremely rare. We report a case of left ovarian endometriosis with endometriosis-induced appendiceal intussusception in a 42-year-old woman presenting with rectal bleeding and left-…

OBJECTIVE: To establish and characterize cell lines derived from human endometrial epithelial cells (ECs) and mesenchymal cells (MCs) from patients with and without endometriosis. DESIGN: In vitro experimental study. SETTING: University a…

Endometriosis has several distinguishing features in the ectopic endometrium, including chronic inflammation and fibrosis. According to the retrograde menstruation theory, endometriotic cells are derived from eutopic endometrial cells, and …

Repeated tissue injury and repair and fibrosis play a pivotal role in endometriosis. Fibrotic tissue consists of extracellular matrix proteins, regulated by transcriptional factors promoting cell proliferation and survival. Periostin is one…

Ovarian endometriosis (OE) provides women of reproductive age with not only severe menstrual pain but also infertility and an increased risk for ovarian carcinogenesis. Whereas peritoneal endometriosis models have been developed with syngen…