Thomas Kolben

OBJECTIVE: The study aimed to evaluate the long-term outcomes of surgical management in patients with peritoneal endometriosis, focusing on postoperative pain trajectories, re-operation rates, fertility outcomes, and the potential influence…

Supplementary Material 1.

Supplementary Material 1.

Supplementary Material 2.

Supplementary Material 2.

Abstract Background Endometriosis is a highly prevalent, hormone-driven chronic disease characterized by the growth of endometrial tissue outside the uterine cavity. Despite its impact, the mechanisms underlying the disease’s pathogenesis r…

Abstract Background Endometriosis is a highly prevalent, hormone-driven chronic disease characterized by the growth of endometrial tissue outside the uterine cavity. Despite its impact, the mechanisms underlying the disease’s pathogenesis r…

BACKGROUND: Endometriosis is a highly prevalent, hormone-driven chronic disease characterized by the growth of endometrial tissue outside the uterine cavity. Despite its impact, the mechanisms underlying the disease’s pathogenesis remain po…

Abstract Study question Do the cardinal symptoms of endometriosis improve after surgery and is the change dependent on localization and extent of lesions according to the #ENZIAN classification? Summary answer Mean VAS scores improved at 6 …

OBJECTIVE: To develop a predictive risk score for superficial peritoneal endometriosis (SPE) in patients with negative examination and imaging, based on symptoms and quality of life measures. DESIGN: Multicenter nested case-control study c…

Endometriosis is a chronic inflammatory disease associated with substantial impairment of quality of life. Although the #ENZIAN classification enables detailed anatomical characterization of disease distribution, its relevance for predictin…

BACKGROUND: The global increase in interest in endometriosis highlights the importance of further investigations concerning this so-called benign gynecological disease. Owing to their severe presentation of symptoms, patients suffer from an…

Study question: Is there an association between pre-operative symptoms and intraoperatively described localization and size of endometriosis lesions as assessed by the #ENZIAN classification system? Summary answer: Dyschezia is associated w…

STUDY QUESTION: Is there an association between pre-operative symptoms and intraoperatively described localization and size of endometriosis lesions as assessed by the #ENZIAN classification system? SUMMARY ANSWER: Dyschezia is associated …

Abstract Study question Can we predict peritoneal endometriosis (PE) in women with pain symptoms who have no signs of endometriosis on examination or imaging studies? Summary answer A calculated score including dysmenorrhea, dysuria, dyspar…

Abstract Study question Do pre-operative symptoms correlate to the localization and size of endometriosis lesions found operatively? Summary answer Dyschezia was associated with deep infiltrating endometriosis (DE) lesions in #ENZIAN compar…

OBJECTIVES: With SARS-CoV-2 evolving, disease severity and presentation have changed due to changes in mechanisms of entry and effector site as well as due to effects of vaccination- and/or infection-acquired immunity. We re-assessed fetal …

Recent research has shed light on the impact of endometriosis on complications during pregnancy, but very few studies address the influence of deep endometriosis (DE) on delivery and peripartum parameters. For this reason, an international …

OBJECTIVES: The chemokine CCL22 is recognized for recruiting immunosuppressive regulatory T-cells (Treg) that contribute to disease progression in various tumor entities helping them to evade the host immune response. Our study aims to iden…

In recurrent epithelial ovarian cancer (EOC) most patients develop platinum-resistance. On molecular level the NRF2 pathway, a cellular defense mechanism against reactive oxygen species, is induced. In this study, we investigate AKR1C1/2, t…