Brenda Ametepe

ORCID: 0009-0007-5914-4999 · 2 papers in corpus

2026

Integrating single-cell and bulk transcriptomic perturbation resources reveals complementary therapeutic spaces for drug repurposing

Research square ·doi:10.21203/rs.3.rs-10606217/v1

BACKGROUND: Transcriptome-based drug repurposing can accelerate therapeutic discovery, but is limited by fragmented resources, inconsistent quality control, and reliance on single perturbation databases. METHODS: We developed CDRPipe (Comp…

other 2026

Integrating single-cell and bulk transcriptomic perturbation resources reveals complementary therapeutic spaces for drug repurposing

bioRxiv : the preprint server for biology ·doi:10.64898/2026.07.17.739227

Transcriptome-based drug repurposing can accelerate therapeutic discovery, but is limited by fragmented resources, inconsistent quality control, and reliance on single perturbation databases. We developed CDRPipe (Computational Drug Repurpo…