Alistair Williams

rct 2023

Ulipristal acetate versus levonorgestrel-releasing intrauterine system for heavy menstrual bleeding: the UCON randomised controlled trial and mechanism of action study

BackgroundHeavy menstrual bleeding affects one in four women and negatively impacts quality of life. The levonorgestrel-releasing intrauterine system is an effective long-term treatment but is discontinued by many due to unpredictable bleed…

other 2021

The endometrial response to modulation of ligand-progesterone receptor pathways is reversible

Fertility and sterility ·doi:10.1016/j.fertnstert.2021.02.008

OBJECTIVE: To study the impact of the progesterone receptor modulator (PRM), ulipristal acetate (UPA), on endometrial morphology and function. DESIGN: Cross-sectional. SETTING: University Research Institute. PATIENT(S): Endometrial biops…

rct 2020

Effects of the levonorgestrel intrauterine system on the endometrium after long-term exposure to mifepristone: Secondary outcomes of a randomized controlled trial

European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2020.06.056

OBJECTIVE: Long-term treatment with progesterone receptor modulators (PRM) is associated with a distinct histological entity termed progesterone receptor modulator associated endometrial changes (PAEC). While accumulating evidence implies t…

review 2020

Physiology of the Endometrium and Regulation of Menstruation

Physiological reviews ·doi:10.1152/physrev.00031.2019

The physiological functions of the uterine endometrium (uterine lining) are preparation for implantation, maintenance of pregnancy if implantation occurs, and menstruation in the absence of pregnancy. The endometrium thus plays a pivotal ro…

review 2015

A review of the endometrial histologic effects of progestins and progesterone receptor modulators in reproductive age women

Contraception ·doi:10.1016/j.contraception.2015.01.008

This review compares the histologic changes that occur in the endometrium following ovulation and progesterone secretion with contraceptive progestins and progesterone receptor modulators (PRMs) that may be used as contraceptive agents in w…

2014

Faculty Opinions recommendation of β-Catenin activation contributes to the pathogenesis of adenomyosis through epithelial-mesenchymal transition.

·doi:10.3410/f.718021608.793491629

2013

Faculty Opinions recommendation of SSEA-1 isolates human endometrial basal glandular epithelial cells: phenotypic and functional characterization and implications in the pathogenesis of endometriosis.

·doi:10.3410/f.718029869.793480436

2012

Faculty Opinions recommendation of Aberrant expression of metastasis-inducing proteins in ectopic and matched eutopic endometrium of women with endometriosis: implications for the pathogenesis of endometriosis.

·doi:10.3410/f.13484062.14861178

2012

Faculty Opinions recommendation of Increased activation of the PI3K/AKT pathway compromises decidualization of stromal cells from endometriosis.

·doi:10.3410/f.717963688.793465577

2011

Faculty Opinions recommendation of Abnormal activation of Ras/Raf/MAPK and RhoA/ROCKII signalling pathways in eutopic endometrial stromal cells of patients with endometriosis.

·doi:10.3410/f.8406958.8862056

2010

Evidence of prokineticin dysregulation in fallopian tube from women with ectopic pregnancy.

Fertility and sterility ·doi:10.1016/j.fertnstert.2009.10.061

ObjectiveTo demonstrate expression and regulation of prokineticins (PROKs) and their receptors (PROKRs) in fallopian tube (FT) from women who are not pregnant and women with ectopic pregnancy (EP).DesignTissue analysis.SettingLarge United K…

2010

Faculty Opinions recommendation of Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium.

·doi:10.3410/f.6478956.6602054

2010

Faculty Opinions recommendation of Clinical outcome in diagnostically ambiguous foci of 'gland crowding' in the endometrium.

·doi:10.3410/f.5045957.4981056

2010

Faculty Opinions recommendation of Treatment of endometriosis with a VEGF-targeted conditionally replicative adenovirus.

·doi:10.3410/f.1255979.1111055

lab-animal 2010

Interleukin-11 in endometrial adenocarcinoma is regulated by prostaglandin F2alpha-F-prostanoid receptor interaction via the calcium-calcineurin-nuclear factor of activated T cells pathway and negatively regulated by the regulator of calcineurin-1

The American Journal of Pathology ·doi:10.2353/ajpath.2010.090403

Interleukin-11 (IL-11) up-regulates the proliferative and invasive capacity of many cancers. Coexpression of glycoprotein 130 (GP130) and IL-11 receptor alpha (IL-11Ralpha) is necessary for high-affinity binding of IL-11 to IL-11Ralpha. Thi…

2009

Attenuated sex steroid receptor expression in fallopian tube of women with ectopic pregnancy.

The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2009-1476

ContextSex steroid hormone receptor (SHR) dynamics are well-documented in human endometrium but have not been comprehensively studied in Fallopian tube (FT).ObjectiveThe aim of the study was to compare expression patterns and hormonal regul…

2009

Faculty Opinions recommendation of Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study.

·doi:10.3410/f.1164372.626108

2009

Faculty Opinions recommendation of Endometrial changes from short-term therapy with CDB-4124, a selective progesterone receptor modulator.

·doi:10.3410/f.1148261.605411

2009

Faculty Opinions recommendation of Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms.

·doi:10.3410/f.1161710.623298

2008

Faculty Opinions recommendation of A new role for activin in endometrial repair after menses.

·doi:10.3410/f.1138927.596022

2008

Faculty Opinions recommendation of Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length.

·doi:10.3410/f.1109156.565039

other 2008

The spectrum of endometrial pathology induced by progesterone receptor modulators

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc ·doi:10.1038/modpathol.2008.19

Progesterone receptor modulators (PRM) are hormonally active drugs effective in the management of endometriosis and uterine leiomyomata. The endometrial effects of progestin blockade by PRMs in premenopausal women are currently being evalua…

nonrandomized-trial 2003

Effect of long-term treatment with low-dose mifepristone on the endometrium

Human Reproduction ·doi:10.1093/humrep/deg022

BACKGROUND: Mifepristone in low daily doses has contraceptive potential by inhibiting ovulation and menstruation. Because follicular development is maintained, the endometrium is exposed to estrogen for prolonged periods unopposed by proges…