Kazunori Imada

ORCID: 0000-0002-0945-0513 · 6 papers in corpus
lab-animal 2025
Novel screening approach for stem cell selective inhibitors and their possible translational therapeutic potential for endometriosis
Reproductive biology ·doi:10.1016/j.repbio.2024.100992

Endometriosis is an estrogen-dependent benign disease characterized by growth of the endometrial tissue outside the uterine wall. Several reports suggest the possibility of the pathogenesis and recurrence of endometriosis being related to f…

lab-animal 2014
Dienogest, a synthetic progestin, down-regulates expression of CYP19A1 and inflammatory and neuroangiogenesis factors through progesterone receptor isoforms A and B in endometriotic cells
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2014.12.008

Dienogest (DNG) is a selective progesterone receptor (PR) agonist and oral administration of DNG is used for the treatment of endometriosis. DNG is considered to act on PR to down-regulate pathophysiological factors associated with endometr…

lab-animal 2013
Dienogest inhibits nerve growth factor expression induced by tumor necrosis factor-α or interleukin-1β
Fertility and sterility ·doi:10.1016/j.fertnstert.2013.10.038

OBJECTIVE: Dienogest (DNG), a selective P receptor (PR) agonist, is used to treat endometriosis. To investigate whether DNG affects nerve growth factor (NGF) expression, we stimulated human endometrial epithelial cells (hEECs) with inflamma…

lab-animal 2011
Dienogest inhibits Toll-like receptor 4 expression induced by costimulation of lipopolysaccharide and high-mobility group box 1 in endometrial epithelial cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2011.09.040

OBJECTIVE: To investigate the effect of dienogest on the expression of Toll-like receptor (TLR) 4 in human endometrial epithelial cells. DESIGN: Prospective basic research study. SETTING: Pharmaceutical research center. PATIENT(S): None.…

review 2009
[Pharmacological and clinical profile of dienogest (DINAGEST Tab. 1 mg)]
Nihon yakurigaku zasshi. Folia pharmacologica Japonica ·doi:10.1254/fpj.133.32
lab-animal 2007
Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile
Steroids ·doi:10.1016/j.steroids.2007.10.003

Dienogest was introduced as an oral progestin. Yet its strong oral potency on endometrial activity is not clearly explained. To circumvent this situation, steroid hormone receptor profiling using transactivation assay and endometrial activi…