Shigehiko Mizutani

diagnostic-accuracy 2021

Placental Leucine Aminopeptidase as a Potential Specific Urine Biomarker for Invasive Ovarian Cancer

Journal of clinical medicine ·doi:10.3390/jcm11010222

BACKGROUND: A non-invasive and sensitive biomarker for the detection of ovarian cancer (OvCa) is lacking. We aim to investigate if urinary placental leucine aminopeptidase (P-LAP) can serve as a reliable biomarker for OvCa. METHODS: P-LAP …

review 2021

Recent Insights into Human Endometrial Peptidases in Blastocyst Implantation via Shedding of Microvesicles

International journal of molecular sciences ·doi:10.3390/ijms222413479

Blastocyst implantation involves multiple interactions with numerous molecules expressed in endometrial epithelial cells (EECs) during the implantation window; however, there is limited information regarding the molecular mechanism underlyi…

case-report 2006

Endometrioid adenocarcinoma arising from endometriosis during 2 years of estrogen replacement therapy after total hysterectomy and bilateral salpingo-oophorectomy

Acta obstetricia et gynecologica Scandinavica ·doi:10.1080/00016340600609103

lab-animal 2002

Premenstrual disappearance of aminopeptidase A in endometrial stromal cells around endometrial spiral arteries/arterioles during the decidual change

The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.87.5.8465

Aminopeptidase A (APA, BP-1) is a membrane-bound zinc metallopeptidase that converts angiotensin II (AngII) into AngIII by selectively hydrolyzing the N-terminal aspartyl residue. AngII has been proposed as a candidate for the initial vasoc…