Li Y

Recent studies have highlighted the crucial role of mechanical properties in the ovarian microenvironment for ovarian function. However, the mechanisms that cause ovarian matrix stiffening during aging remain incompletely understood. Here w…

BACKGROUND: Age-related diminished ovarian reserve (DOR) exhibits marked significant individual variation. Some women of advanced age with normal ovarian reserve (NOR) achieve better reproductive outcomes than age-matched DOR patients. OBJE…

Breast cancer prognosis and treatment outcomes are shaped by intricate interplay between tumor biology, systemic comorbidities, and patient-reported functional status. This paper introduces a framework to address critical gaps in precision …

BACKGROUND: Intracytoplasmic sperm injection (ICSI) is performed in over half of assisted reproductive technology cycles globally; however, the optimal interval between oocyte denudation and sperm injection remains undefined in clinical gui…

PURPOSE: The goal of optimizing electrogram acquisition in electrophysiology imaging is to minimize the number of electrodes used, determine their optimal placement, and ensure accurate imaging. METHODS: We quantitatively evaluated the imp…

BACKGROUND: Endometriosis (EMs) is a chronic inflammatory disease often treated with blood-activating and stasis-resolving therapies. Anxiety and depression are common mental comorbidities in patients with EMs. There are no medications avai…

PURPOSE: Pain-related fear (PRF) is increasingly recognized as a clinically relevant psychological factor in chronic pain, yet its role in attentional processing across varying threat levels remains unclear, particularly in functional visce…

BACKGROUND: Managing failure after an initial assisted reproductive technology (ART) cycle remains a significant clinical challenge. Clinicians often face a dilemma between repeating the index protocol, escalating gonadotropin (Gn) dosages,…

PURPOSE: To evaluate prediction models for acute postoperative pain (AOPP) and chronic postsurgical pain (CPSP) after cancer surgery, prioritizing pain phenotype and cancer type. PATIENTS AND METHODS: Four databases were searched through F…

Endometriosis is a common gynecological disorder characterized by the ectopic growth of endometrium-like tissue outside the uterine cavity and is associated with pelvic pain, infertility, and reduced quality of life. Although several theori…

The B‑cell translocation gene 2 (BTG2), originally identified as a tumor suppressor, has been extensively studied in oncology research. However, its multifaceted functions in non‑tumor diseases are still being recognized but not entirely un…

OBJECTIVE: To identify the risk factors associated with postoperative recurrence of unusual (special-type) uterine smooth muscle neoplasia (USMN) and to construct and interpret a machine-learning model for recurrence risk. METHODS: We carr…

Hysterectomy is the regimen of choice for benign gynecologic diseases, including uterine myoma, adenomyosis, endometriosis, and genital prolapse. Surgeons choose hysterectomy methods based on clinical situations or patients' preferences. Ev…

OBJECTIVE: To assess the safety and efficacy of percutaneous intrauterine hydrodissection as a protective technique during microwave ablation (MWA) of uterine fibroids adjacent to the endometrium. MATERIALS AND METHODS: A retrospective ana…

BACKGROUND: LY01021 is a novel oral small-molecule gonadotropin-releasing hormone (GnRH) receptor antagonist intended for the treatment of various sex hormone-dependent disorders. This study aimed to evaluate the safety, tolerability, pharm…

OBJECTIVES: The aim of this study was to examine SEMA3C expression in endometriosis (EMs) and its relationship with ferroptosis in human endometrial stromal cells (HESCs). DESIGN: This experimental study used patient tissue samples and in …

Serous borderline tumors (SBTs) typically arise from the ovary, and their development within a paratubal cyst is an uncommon occurrence. We report a 22-year-old nulliparous woman with chronic dysmenorrhea and an enlarging right adnexal cyst…

Pregnant women undergoing assisted reproductive technology (ART) have an increased risk of gestational diabetes mellitus (GDM), potentially linked to altered immune regulation, but the underlying circulating immune features remain unclear. …

Single-cell and spatial omics have revolutionized biomedical research by enabling high-resolution molecular profiling across cells and tissues, thereby overcoming key limitations of bulk sequencing and revealing unprecedented cellular heter…

Hysterectomy is a frequent gynecological surgical technique. With the extensive application of robot-assisted laparoscopic surgery, the feasibility of robot-assisted transvaginal natural orifice translumenal endoscopic surgery (v-NOTES) has…

BACKGROUND: Disrupted sleep and shift work are linked to multiple adverse health outcomes, but their association with reproductive endocrine disorders (REDs) and underlying mechanisms remain unclear. Understanding this relationship is cruci…

BackgroundHerlyn-Werner-Wunderlich syndrome (HWWS) is a rare congenital Müllerian anomaly characterized by uterus didelphys, obstructed hemivagina, and ipsilateral renal anomaly. Recurrence after prior surgical treatment is particularly rar…

OBJECTIVES: M2 macrophages enriched in endometriotic lesions are involved in immune evasion and angiogenesis, while the migratory capacity of ectopic endometrial stromal cells is also closely associated with lesion progression. However, whe…