Louise Brinton

No ORCID on file · 4 papers in corpus · active 2013-2016

Study types

  • other 2
  • article 1
  • meta-analysis 1

Condition tags

  • endometriosis 4
  • mesh:D004715 1
other 2016
Assessment of Multifactor Gene-Environment Interactions and Ovarian Cancer Risk: Candidate Genes, Obesity, and Hormone-Related Risk Factors
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology ·doi:10.1158/1055-9965.EPI-15-1039

BACKGROUND: Many epithelial ovarian cancer (EOC) risk factors relate to hormone exposure and elevated estrogen levels are associated with obesity in postmenopausal women. Therefore, we hypothesized that gene-environment interactions related…

article 2015
Shared genetics underlying epidemiological association between endometriosis and ovarian cancer
Human molecular genetics ·doi:10.1093/hmg/ddv306

Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associatio…

other 2014
Risk of ovarian cancer and the NF-κB pathway: genetic association with IL1A and TNFSF10
Cancer research ·doi:10.1158/0008-5472.CAN-13-1051

A missense single-nucleotide polymorphism (SNP) in the immune modulatory gene IL1A has been associated with ovarian cancer risk (rs17561). Although the exact mechanism through which this SNP alters risk of ovarian cancer is not clearly unde…

meta-analysis 2013
Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology ·doi:10.1158/1055-9965.EPI-12-1030-T

BACKGROUND: There are several well-established environmental risk factors for ovarian cancer, and recent genome-wide association studies have also identified six variants that influence disease risk. However, the interplay between such risk…