Jae Hee Lee — Endo Lab

lab-animal 2015

Mig-6 regulates endometrial genes involved in cell cycle and progesterone signaling

Biochemical and biophysical research communications ·doi:10.1016/j.bbrc.2015.04.146

Mitogen inducible gene 6 (Mig-6) is an important mediator of progesterone (P4) signaling to inhibit estrogen (E2) signaling in the uterus. Ablation of Mig-6 in the murine uterus leads to the development of endometrial hyperplasia and E2-ind…

lab-animal 2013

Extracellular signal-regulated kinase 1/2 signaling pathway is required for endometrial decidualization in mice and human

PloS one ·doi:10.1371/journal.pone.0075282

Decidualization is a crucial change required for successful embryo implantation and the maintenance of pregnancy. During this process, endometrial stromal cells differentiate into decidual cells in response to the ovarian steroid hormones o…

lab-animal 2013

Signal transducer and activator of transcription-3 (Stat3) plays a critical role in implantation via progesterone receptor in uterus

FASEB journal : official publication of the Federation of American Societies for Experimental Biology ·doi:10.1096/fj.12-225664

Recent studies have shown that activation of the signal transducer and activator of transcription-3 (Stat3) is required for decidualization, interacting with progesterone receptor (PR) in uterus. Based on previous reports, we hypothesized t…