Chunfang Ha

Background Stromal heterogeneity, regulated-cell-death-associated stress, and chronic inflammation contribute to endometriosis, but their relationships within specific stromal populations remain incompletely understood. This study integrate…

BACKGROUND: Endometriosis (EM) is associated with immune dysregulation, while dysfunction of natural killer (NK) cells is regarded as a key mechanism underlying immune escape and the persistent growth of ectopic lesions. METHOD: This study…

BACKGROUND: The optimal surgical approach for hysterectomy in patients with complex large uteri remains controversial, particularly in those with uterine enlargement and obesity. This study aimed to compare perioperative outcomes and compli…

Endometriosis is a refractory estrogen-dependent gynecological disease in which ovarian endometriosis(OE) is the most common, and the main cell components are endometrial epithelial cells and stromal cells. However, constructing ectopic end…

BACKGROUND: Endometriosis (EMs), characterized by ectopic endometrial growth causing infertility. Endoplasmic reticulum stress (ERS) is an important cellular defense mechanism. However, the correlation between ERS and EMs remains unclear. W…

Endometriosis is a prevalent condition with notable impacts on fertility. Recent studies have implicated gut microbiota in the development of endometriosis associated infertility (EAI). This study employs Mendelian randomization (MR) to elu…

Endometriosis is an aggressive disease. It is the main cause of chronic pelvic pain, dysmenorrhea, and infertility, affecting the well-being of women. This study aimed to explore the role of U0126 and BAY11-7082 in endometriosis (EMs) treat…

BACKGROUND: Endometriosis (EMs) is a benign chronic condition that tends to recur in women of childbearing age, with an incidence of approximately 10%. It is a multifactorial disease for which the pathogenesis is currently unclear. This stu…

Objectives: The aim of this study is to investigate the relationship between the Nuclear factor-kappa B (NF-κBp65) and RAS/MEK/ERK signaling cascade and their influence on the proliferation and invasion of endometrial stromal cells. Design:…

Introduction Endometriosis is a reproductive disorder closely associated with hypoxia stress. Increasing evidences have implied the important roles of angiotensin II (ANG II) receptors in the pathophysiology of endometriosis. Thus, we specu…

PURPOSE: Although the clinical effect of dienogest for endometriosis after conservative surgery has been proven, the cost-effectiveness of this new pharmacotherapy remains to be determined. We aimed to assess the health economic implication…

BACKGROUND: Endometriosis, which shares certain characteristics with cancers, may cause abnormal expression of proteins involved in cell migration. Endometrial epithelial cells (EECs) are believed to play an important role in endometriotic …

Objective To explore the expression features of OPN and MMP-9 in different tissues and the effect of mifepristone on the endometriosis models in rats Methods Of 13EMS model rats,6 rats were randomly selected as the control group(N group),wh…

Objective To research the reliability,evaluation index and achievement ratio of an opening-method model of endometriosis in rats compared with the transplanting-method.Methods Female virginal rats were operated on with the opening-method(th…

Objective To analyze the expression of OPN and MMP-9 in ectopic endometrium and the relationship between OPN expression and MMP-9 in endometriosis.Methods The ectopic endometrial tissue(ectopic group) and eutopic endometrium from 37 pre-bui…