Minnie Malik

ORCID: 0000-0003-1129-6575 · 4 papers in corpus
lab-animal 2024
Coenzyme Q-10 reduced the aberrant production of extracellular matrix proteins in uterine leiomyomas through transforming growth factor beta 3
F&S science ·doi:10.1016/j.xfss.2024.07.004

OBJECTIVE: To evaluate the impact of coenzyme Q-10 (CoQ-10) on the dysregulated synthesis of extracellular matrix proteins mediated by transforming growth factor beta 3 (TGF-β3) in uterine leiomyomas. DESIGN: Laboratory study. SETTING: Un…

lab-animal 2022
Curcumin inhibits human leiomyoma xenograft tumor growth and induces dissolution of the extracellular matrix
F&S science ·doi:10.1016/j.xfss.2022.10.004

OBJECTIVE: To determine whether a curcumin-supplemented diet would prevent and/or treat uterine leiomyoma growth in our mouse xenograft model. DESIGN: Animal study. SETTING: Laboratory study. PATIENT(S): N/A. INTERVENTION(S): Curcumin-s…

lab-animal 2020
Simvastatin ameliorates altered mechanotransduction in uterine leiomyoma cells
American journal of obstetrics and gynecology ·doi:10.1016/j.ajog.2020.05.012

BACKGROUND: Uterine leiomyomas, the most common tumors of the female reproductive system, are characterized by excessive deposition of disordered stiff extracellular matrix and fundamental alteration in the mechanical signaling pathways. Sp…

other 2007
Uterine leiomyomas express a molecular pattern that lowers retinoic acid exposure
Fertility and sterility ·doi:10.1016/j.fertnstert.2006.11.093

OBJECTIVE: To analyze expression of the retinoic acid signaling pathway genes that are involved in retinol metabolism, transport, transcriptional activation, and transcriptional products in spontaneous human leiomyomas. DESIGN: Laboratory …